To reroute a cytokine’s signaling, Abhiraman et al. generated soluble adaptors comprising units that bind to two sites on a cytokine linked to units that bind to and compel dimerization/activation [...] bit.ly/4l0nd2G @stanfordmedicine.bsky.social @gitaabhiraman.bsky.social
Many thanks to Chris Garcia, Karsten Householder, @graysonrodriguez.bsky.social, Caleb Glassman, Robert Saxton, our collaborators @retickerflynn.bsky.social, Cort Breuer, Venu Pillarisetty at UW, and several others in the Garcia lab who contributed to this work!
As proof of concept, we design cytokine adaptors that convert TGF-b or IL-10 into IL-2 receptor agonists to reverse T cell suppression, with potential applications in cancer therapy.