TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins by @XianghuaLi2
Are Transcription Factors really 'undruggable'?
www.biorxiv.org/content/10.1...
The Gaza Famine is the world’s famine. A preventable, predictable famine.
Enough. Ceasefire. Open all crossings, north and south. Let us get food in, unimpeded and at massive scale.
An HNF1A-A1CF transcription splicing axis regulates insulin secretion, and breaks down in T2D.
Amazing work led by Edgar Bernardo + Matias de Vas + major contributions from Diego Balboa, Silvia Bonas, Mirabai Cuenca, Fanny Mollandin, Merce Planas, Miquel Torrent, MA Maestro and many others
A HNF1A-A1CF transcription-splicing axis is suppressed in β cells from #T2D individuals, while genetic variants reducing pancreatic islet A1CF are associated with increased glycemia and T2D susceptibility www.cell.com/cell-metabol...
Video
Bernardo et al. uncover a transcription-splicing regulatory axis driven by HNF1A and
A1CF in pancreatic β cells. Targeted perturbations, single-cell studies, and human
genetic evidence demonstrate tha...
www.cell.com
Transcription factors (TFs) bind specific DNA sequences to control gene expression. Modulating TF activity is of considerable therapeutic interest but very few TFs have been successfully drugged. TF D...
Bernardo et al. uncover a transcription-splicing regulatory axis driven by HNF1A and
A1CF in pancreatic β cells. Targeted perturbations, single-cell studies, and human
genetic evidence demonstrate tha...
www.cell.com
Ben Lehner
Daniel Drucker
Jorge Ferrer
Tom Fletcher
Congratulations for this study in @Dev_journal, no small feat in Argentina's anti-Science climate
Many exciting opportunities for a PhD in Life Sciences in CRG, Barcelona. If you are interested in Genomics of Diabetes check out the offer for a fully funded fellowship in our lab - we will consider candidates with experimental or computational backgrounds.
Please spread the word!
These are VERY rough estimates, but here's life expectancy after diagnosis of type-I diabetes over the past 150 years.
It was Banting and Best's discovery of how to isolate insulin in 1921 — not some fucking cooking class — that gave people including my daughter a new lease on life.
Join is in Budapest in October! For the 6th time, all things epigenetics, gene and genome regulation and more. A fantastic opportunity to present, to talk to speakers and colleagues in a friendly, informal setting at a great location. Please note, travel grant deadline will expire soon.
Jorge Ferrer
Jorge Ferrer
Carl T. Bergstrom
Ferenc Mueller
📣 New PRBB-CRG conference
📋 Mapping progenitor niche dynamics for regulation of cell fate
🗣️ Francesca Spagnoli (@labspagnoli.bsky.social) - @kingscollegelondon.bsky.social
📆 May 22 - ⏰ 12:00
hosted by: @jorge-ferrer.bsky.social - @crg.eu
📍 #PRBB Maria Skłodowska-Curie room
SUM-seq out @natmethods.nature.com !
🚀 Ultra-high-throughput Multiplexed snATAC+RNA
Used to:
⏳ link temporal macrophage GRNs to immune disease genetics
🩸 map T cell regulatory landscapes
🧬✂️ dissect TF function in hiPSC differentiation via CRISPRi/a screens
doi.org/10.1038/s41592-025-02700-8
🧵
This work presents SUM-seq, an ultra-high-throughput method for co-profiling chromatin accessibility and gene expression in single nuclei across multiplexed samples, advancing the study of gene regula...
Are you looking for a PhD? Join us in Barcelona! You'll dive into a community of >100 PhD students from 30 countries exploring the frontiers of biology. You can also join an online workshop on 6 November (15:00 CET) to learn how to find the right lab for you.
More info: www.crg.eu/en/content/t...
Mikael Marttinen
Parc de Recerca Biomèdica de Barcelona
Centre de Regulació Genòmica (CRG)
Thrilled to announce a major milestone for our lab @ifibyne @Exactas_UBA — our paper on the glucocorticoid receptor's role in early pancreas development is now published in @Dev_journal!
Huge thanks to @vallierlab.bsky.social for this long-term collaboration!👇🧵
🔗 doi.org/10.1242/dev....
