An HNF1A-A1CF transcription splicing axis regulates insulin secretion, and breaks down in T2D.
Amazing work led by Edgar Bernardo + Matias de Vas + major contributions from Diego Balboa, Silvia Bonas, Mirabai Cuenca, Fanny Mollandin, Merce Planas, Miquel Torrent, MA Maestro and many others
Bernardo et al. uncover a transcription-splicing regulatory axis driven by HNF1A and
A1CF in pancreatic β cells. Targeted perturbations, single-cell studies, and human
genetic evidence demonstrate tha...
