A HNF1A-A1CF transcription-splicing axis is suppressed in β cells from #T2D individuals, while genetic variants reducing pancreatic islet A1CF are associated with increased glycemia and T2D susceptibility www.cell.com/cell-metabol...
Bernardo et al. uncover a transcription-splicing regulatory axis driven by HNF1A and
A1CF in pancreatic β cells. Targeted perturbations, single-cell studies, and human
genetic evidence demonstrate tha...
