A clinician scientist at LTRI @sinaihealth studying Glucagon, GIP, GLP-1, GLP-2, diabetes, obesity, metabolism and the gut endocrine system
Daniel Drucker
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Irisin induction in response to exercise confers direct neuroprotective effects in an inflammation-driven neurodegenerative condition in mice, making it an attractive therapeutic candidate for multiple sclerosis @natmetabolism.nature.com www.nature.com/articles/s42...
New experimental insights into vagal mechanisms triggered by allulose to improve insulin sensitivity diabetesjournals.org/diabetes/art...
Here the authors highlight potential therapeutic benefits of 4 weeks of β2-AR stimulation for improving muscle-specific glucose uptake in individuals with or at risk for developing diabetes #T2D www.nature.com/articles/s41...
Revisiting changes in cognitive function and biomarkers of Alzheimer’s disease in REWIND alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Amyloid-dependent StAR upregulation in beta cells under conditions of islet amyloid deposition could contribute to mitochondrial dysfunction @diabetologiajnl.bsky.social
link.springer.com/article/10.1...
A potentially targetable pathogenic signature of EV-associated miRNAs capable of stratifying type 1 diabetes risk #islets @diabetologiajnl.bsky.social
link.springer.com/article/10.1...
Could Ozempic be the solution to inflammatory diseases? Perhaps not for all of them, but compelling research from @danieljdrucker.bsky.social's lab and others is exploring where GLP-1s' anti-inflammatory properties could have meaningful clinical benefits. My latest @sciam.bsky.social
Daniel Drucker
Supporting the concept that GLP1 agonist drugs lower blood pressure independent of weight loss: doi.org/10.1172/jci....
@danieljdrucker.bsky.social & team @sinaihealth.bsky.social identify the vascular smooth muscle GLP-1 receptor as a key cellular target for GLP-1s to lower BP
🏆We're proud to announce Prof. Anette Ziegler as the recipient of the 58th EASD Claude Bernard Prize: the highest honour our association bestows.Her career has been driven by 1 vision: a world w/out #T1D.
Join us in celebrating her at #EASD2026.
🔗👉 www.easd.org/prizes/claud...
Supported by Sanofi
Honored to share that Dr. Gökhan Hotamışlıgil has been elected to the National Academy of Sciences, one of the highest distinctions in science recognizing outstanding, sustained contributions to research.
Huge congratulations to Dr. Hotamışlıgil on this remarkable and well-deserved honor!
Daniel Drucker
Daniel Drucker
Daniel Drucker
Daniel Drucker
Daniel Drucker
Lauren J. Young
Harvard Molecular Metabolism
European Association for the Study of Diabetes
JCI insight
Exercise-mediated neuroprotection in a mouse model of multiple sclerosis is reduced in mice lacking the irisin-encoding gene, Fndc5, and can be recapitulated by peripheral administration of irisin.
The study showed in a placebo-controlled crossover design that 4-week treatment with β2-adrenergic agonist clenbuterol enhances insulin-stimulated glucose uptake in skeletal muscle but not brown adipo...
INTRODUCTION This post hoc analysis of the Researching Cardiovascular Events with a Weekly Incretin in Diabetes (REWIND) trial examined associations between dulaglutide, Alzheimer's disease and rela...
Aims/hypothesis Loss of islet beta cell function and mass are critical in the pathogenesis of type 2 diabetes, a disease in which ~90% of individuals exhibit islet amyloid deposition. Amyloid deposits...
WASHINGTON — The National Academy of Sciences announced today the election of 120 members and 25 international members in recognition of their distinguished and continuing achievements in original res...
