Irisin induction in response to exercise confers direct neuroprotective effects in an inflammation-driven neurodegenerative condition in mice, making it an attractive therapeutic candidate for multiple sclerosis @natmetabolism.nature.com www.nature.com/articles/s42...
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Exercise-mediated neuroprotection in a mouse model of multiple sclerosis is reduced in mice lacking the irisin-encoding gene, Fndc5, and can be recapitulated by peripheral administration of irisin.
