📣Our paper is out! 🤩 We found that local modification of H3K9me3 using CRISPR/dCas9 at hotspots changes crossover activity, bringing us closer to targeted recombination in plants.🌱
Huge thanks to @szymanskalejman.bsky.social, Wojtek, Ania, and Karolina!
www.science.org/doi/10.1126/...
Targeting chromatin modifiers to DNA hotspots reveals causal link between histone marks, transcription, and meiotic recombination.
I am happy to announce the launch of a new Arabidopsis genomics resource! Check out arabidopsislyrata.org Now you can easily look at the natural genetic variation across the entire species range of A. lyrata and A. arenosa.
Can we tune a plant’s epigenetic toolkit to disrupt plant homeostasis in ways that enable phenotypic innovation?
🌱Check out our new Opinion Paper with @thanvisrikant.bsky.social discussing this topic in @cp-trendsplantsci.bsky.social!
www.sciencedirect.com/science/arti...
Resequencing hundreds or thousands of individuals from the same species has become routine... but processing all those genomes efficiently? Still a headache!
Here's my solution that used to be lab-internal but that I am happy to share:
crolllab.github.io/genomepanel_...
Polina Novikova
Nextflow pipeline for reference genome mapping, SNP calling and quality checks on large genome panels
We identified an initial set of 30+ toolkit genes from literature, but encourage the community to test & expand our model! Further questions incl. (1) how similar/diverse toolkits function across environments (2) how toolkit proteins affect (epi)genomic features in various cells/tissues/individuals
