Paying peer reviewers works.
Expanded Fast & Fair experiment @biologyopen.bsky.social:
• 5.5 vs 37.7 working days to decision with reviews
• ~3 vs ~9 reviewer invitations per manuscript
• no reduction in editor-assessed review quality
• similar acceptance rates
www.biorxiv.org/content/10.6...
🚨 Why can’t mammals regenerate limbs like frog tadpoles or salamanders?
In our new paper in @science.org , we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸
🔗 www.science.org/doi/10.1126/... #EvoDevo
Published in @natmed.nature.com today, Stephen Mayhew, Dave Allan and David Roblin share ten lessons learned from a decade of translating science at the Crick towards health and societal impact.
www.nature.com/articles/s41...
New paper out in @cp-cellstemcell.bsky.social. We uncover unexpected complexity in how metabolism changes when the embryo implants or when stem cells exit naive pluripotency, revealing a central role for dynamic TCA cycle rewiring in cell fate decisions. www.cell.com/cell-stem-ce...
A biochemical curiosity: it is much more straightforward to go enzymatically from 5mC > T than it is to go from 5mC > C
Absolutely thrilled 💣 to share our preprint 🖨️: "Mapping active cis-regulatory elements from transcription initiation events”.
www.biorxiv.org/content/10.6...
We introduce nucCAGE and PRIME to identify active cis-regulatory elements (CREs) and disease-associated, non-coding variants.
Why mammals cannot regenerate limbs like amphibians do presents a long-standing puzzle in biology. To uncover the underlying differences, we compared amputation responses of embryonic mouse (Mus musculus) and Xenopus laevis tadpole limbs. Lowering ...
Online Now: Gut microbiota modulation of regulatory DNA elements revealed by massively parallel functional characterization Online now:
Meet our Preprint Editors
We are pleased to welcome our first group of Preprint Editors to our editorial team, responsible for handling our 'In preprints' articles. #preprints
journals.biologists.com/dev/pages/ed...
Human embryo editing against disease is unsafe and unproven — despite rosy predictions www.nature.com/articles/d41...
Daniel Gorelick
Using carbon tracing and functional experiments, Kafkia, Pladevall-Morera, et al.
show that TCA cycle rewiring underlies mouse embryo implantation and the exit from
naive pluripotency. In this context...
Greg was already a world-renowned scientist when appointed Director, and for the community, he was a visionary leader, a cherished mentor, and a singular force of nature whose influence shaped the research landscape.
Those amazing #phages 🦠 figured out 5mC chemistry before we did:
📄 Out today in @MolecularCell we describe a 5mC-selective #deaminase family in environmental phage genomes with broad applications for #5base #sequencing
#epigenetics #DNAmethylation #genomics #NGS 🧬🧪
www.cell.com/molecular-ce...
To maintain metabolic homeostasis, the liver rapidly adjusts gene expression in response to nutrients, endotoxins, and microbial metabolites derived from the gut. Zaratiana et al. identify microbiota-responsive cis-regulatory elements in hepatocytes. Their results suggest that microbial metabolites modulate the activities of host regulatory DNA elements to shape hepatocyte transcriptional programs.
