Online Now: Gut microbiota modulation of regulatory DNA elements revealed by massively parallel functional characterization Online now:
To maintain metabolic homeostasis, the liver rapidly adjusts gene expression in response to nutrients, endotoxins, and microbial metabolites derived from the gut. Zaratiana et al. identify microbiota-responsive cis-regulatory elements in hepatocytes. Their results suggest that microbial metabolites modulate the activities of host regulatory DNA elements to shape hepatocyte transcriptional programs.
