Wu and Hegde annotate and analyze the topology of 4,863 human endoplasmic reticulumโinserted membrane proteins and their 20,546 transmembrane domains, showing that transmembrane domains inserted by different pathways can tolerate different biophysical properties. rupress.org/jcb/article/...
Heidelberg University Biochemistry Center @bzh-hd.bsky.social is looking for a #professor of #biochemistry. Please spread the wordโผ๏ธ www.bzh.uni-heidelberg.de
Nature research paper: Cellular water-potential sensing through biomolecular condensation
go.nature.com/4ux038v
www.nature.com/articles/s41...
Dear #plantscience friends, we're looking to recruit a new colleague at @uni-freiburg.de @biologyunifreiburg.bsky.social: a Professor in Plant Biotechnology. ๐ฑ๐งช The @dompsfr.bsky.social community is truly fantastic. Interested? Please share far and wide and join us!
uni-freiburg.de/en/job/00005...
๐ฑUpdate on our preprint "๐๐ถ๐ต๐ฐ๐ฑ๐ฉ๐ข๐จ๐บ ๐ข๐ด ๐ข ๐ด๐ฑ๐ข๐ต๐ช๐ข๐ญ ๐ฐ๐ณ๐จ๐ข๐ฏ๐ช๐ป๐ฆ๐ณ ๐ฐ๐ง ๐ฑ๐ญ๐ข๐ฏ๐ต ๐ช๐ฎ๐ฎ๐ถ๐ฏ๐ช๐ต๐บ"
www.biorxiv.org/content/10.6...
1) ๐งฌ mesophyll autophagy rescues ETI; guard cell autophagy does not
โก PTI competence likely requires autophagy across tissuesโnot just in mesophyll or guard cells.
๐ฑSeedling emergence needs active mitochondria but that invites damage. Enter SPL2, a mitochondrial E3 ligase. It degrades outer membrane proteins to reduce ER-mitochondria tethering & mitophagy
Light boosts SPL2. Mitophagy drops. Seedling pushes via soil #plantscience www.nature.com/articles/s41...
Plants sense water deficiency through SAM8 protein condensation, which responds to reduced hydration and triggers stress adaptation by altering RNA export and gene translation.
This study reveals a mechanism by which plants control mitochondrial quality during seedling emergence. The authors identify the protein SPL2, which tags damaged mitochondria for degradation, thereby ...
www.nature.com
www.nature.com/articles/s41...
๐ฑ๐งฌ SnRK2.6 phosphorylates and stabilizes PTRE1, which boosts 26S proteasome activity during ABA signaling. Loss of PTRE1 increases ABI5 levels and enhances ABA sensitivity.
A dual mechanism fine tunes ABA responses #plantscience @mplantpcom.bsky.social
www.cell.com/plant-commun...
Cell Biology J-Club
ATG8 conjugation on damaged lysosomes triggers rapid assembly of a protein complex containing TFG, which directs lysosomal membrane repair by recruiting ESCRT proteins to sites of damage.
This study reports that abscisic acid (ABA) activates sucrose nonfermenting 1-related
kinase 2.6 (SnRK2.6), which phosphorylates proteasome regulator 1 (PTRE1) and inhibits
its degradation, thereby st...
Preprint alert ๐จ (1/10) ๐งต
๐๐ถ๐ต๐ฐ๐ฑ๐ฉ๐ข๐จ๐บ ๐ช๐ด ๐ข ๐ฑ๐ข๐ณ๐ข๐ฅ๐ฐ๐น ๐ช๐ฏ ๐ฑ๐ญ๐ข๐ฏ๐ต ๐ช๐ฎ๐ฎ๐ถ๐ฏ๐ช๐ต๐บ:
It can promote resistance, susceptibility, or restrict cell death ๐คฏ
So what is its actual role?
We show it acts as a spatial organizer of immunity across cell types ๐ฑ๐ฆ #proteostasis
www.biorxiv.org/content/10.6...
