GLYCAN ATLASSING: NANOSCALE ANALYSIS OF GLYCOCALYX ARCHITECTURE ENABLES FUNCTIONAL TRACING OF CELL STATE 🍭🔬🧬
Don’t judge a book by its cover - judge a cell by its cover! We can now trace how cell state is encoded in glycocalyx state. #glycotime #microscopy
www.biorxiv.org/content/10.1...
Leonhard Möckl
NEW PREPRINT: Spatial mapping of cell-surface protein glycosylation at molecular resolution 🍭🍬🔬
For the first time, we can analyze the spatial architecture of the cell-surface glycoproteome at single-protein and single-sugar resolution. #glycotime
www.biorxiv.org/content/10.1...
Glycan Atlassing is online at @natnano.nature.com! Thanks to everyone involved, especially to @dijo-mj.bsky.social and @nazlicanyurekli.bsky.social who spearheaded the work. Read the paper here: dlvr.it/TSXNDb
#Glycotime
Very happy to see this one out - the first molecular-resolution imaging of glycocalyx components in their native environment! Great collaboration with @jungmannlab.bsky.social - congrats to first authors @karimalmahayni.bsky.social and @lumasullo.bsky.social and to the whole team!
Leonhard Möckl
Leonhard Möckl
Leonhard Möckl
Won the best poster award :) at #SMLMS2025 @smlm-symposium.bsky.social together with Sanne Giezen. Thanks to my mentor @lmoeckl.bsky.social and colleague @nazlicanyurekli.bsky.social and all the members of Möckl lab.
Attended #SMLMS2025 last week in Bonn, Germany. Many thanks to the organizers @uendesfelder.bsky.social @heilemannlab.bsky.social and Prof. Kubitscheck for introducing #youngSMLMS. That was really mindful of the young researchers including me:). Had a great time in Bonn discussing science.
dijo_mj
dijo_mj
Cell-surface protein glycosylation is a fundamental post-translational modification that plays a crucial role in membrane protein function and cellular behavior. However, elucidating the molecular spa...
Multiplexed super-resolution microscopy of DNA-barcoded lectins and metabolically incorporated unnatural sugars quantitatively links the nanoscale spatial relationships of glycocalyx organization and ...
Thrilled to announce that our paper on Glycan Atlassing is officially published in Nature Nanotechnology!🧬🍭
We developed "Glycan Atlassing," a method to map the glycocaly at nanometer resolution. This allows us to trace cellular states and opens new avenues for diagnostics and therapy..
New paper online:
Ångström-resolution imaging of cell-surface glycans.
The molecular organization of sugars in the native #glycocalyx has been resolved at 9 ångström using bioorthogonal metabolic labeling and #superresolution imaging of DNA barcodes.
#Glycotime
www.nature.com/articles/s41...
By combining bioorthogonal metabolic labelling and resolution enhancement through sequential imaging of DNA barcodes, the molecular organization of individual sugars in the native glycocalyx has been ...
Nature Nanotechnology
Nature Nanotechnology, Published online: 14 May 2026; doi:10.1038/s41565-026-02151-yMultiplexed super-resolution microscopy of DNA-barcoded lectins and metabolically incorporated unnatural sugars quantitatively links the nanoscale spatial relationships of glycocalyx organization and cellular state.
