FabF and FadM cooperate to recycle fatty acids and rescue ∆plsX lethality in Staphylococcus aureus:
👇
dx.plos.org/10.1371/jour...
#staph
Great to see Sam's work on PdhD out now in Microbiology! Very cool story showing how subtle metabolic adaptations can give Staph an edge during systemic invasion #microsky
www.microbiologyresearch.org/content/jour...
Interesting insights into the role of S aureus PSMs in macrophage infection! #microsky
You are an ambitious young scientist, on the verge to independence, in a research field related to our Cluster of Excellence @cmfi.bsky.social “Controlling Microbes to Fight Infections”? Join our vibrant, interactive scientific community in Tubingen. Repost and apply!
www.nature.com/naturecareer...
The Cluster of Excellence EXC 2124 “Controlling Microbes to Fight Infections” (CMFI) at the University of Tübingen invites applications for Indepen...
www.nature.com
Author summary Phospholipids are vital cell membrane components. The essential Staphylococcus aureus phospholipid synthesis enzyme PlsX uses acyl-ACP, the end-product of fatty acid (FA) synthesis (FAS...
Methicillin-resistant Staphylococcus aureus (MRSA) is a key pathogenic bacterium and poses a significant therapeutic challenge due to its developing resistance to therapeutics. Here the authors establ...
www.nature.com
Staphylococcus aureus is a leading cause of bloodstream infections causing an estimated 300,000 deaths worldwide. Using a functional genomics approach, our group previously identified that adaptation ...
😱 Transposable elements are driving rapid adaptation of Enterococcus faecium:
www.nature.com/articles/s41...
@nature.com
www.nature.com
Over three decades, rapid expansion of the transposable element ISL3 has reshaped Enterococcus faecium, which helps to explain this pathogen’s growing clinical threat.
Transposable elements are driving rapid adaptation of Enterococcus faecium
-in @nature.com from Ami Bhatt
www.nature.com/articles/s41...
Commensal bacteria are crucial for microbiome interactions and pathogen exclusion but are often very difficult to tackle genetically. Our new paper describes an intriguing advance:
@cmfi.bsky.social @dzif.bsky.social @spp2330.bsky.social
www.sciencedirect.com/science/arti...
www.nature.com
Over three decades, rapid expansion of the transposable element ISL3 has reshaped Enterococcus faecium, which helps to explain this pathogen’s growing clinical threat.
Increasing recognition of commensal bacteria as essential for microbiome integrity and pathogen exclusion underscores the urgency of molecularly chara…
Read the thread by first author Bohdana Hurieva, who explains our findings on the catalyitc activities of animal TIRs in more details:
bsky.app/profile/bhur...
🎉Excited to share our new preprint!
TIR domains from diverse animals, including human TLR4, are catalytically active and produce cyclic ADP-ribose (cADPR). This enzymatic activity is widespread in animals and conserved across the tree of life.
www.biorxiv.org/content/10.6...
www.biorxiv.org
Bohdana Hurieva🇺🇦
Thank you @michiwagner4.bsky.social for your seminar talk. Looking forward to close ties between @microbesplanet.bsky.social and @cmfi.bsky.social
Sorek Lab
Andreas Peschel
It turns out bacteria can make and secrete bacteriocins from transmembrane proteins. Check out our new study led by Fauzia Nur.
👇
www.biorxiv.org/content/10.6...
www.biorxiv.org
Many thanks @andreaspeschel.bsky.social for inviting me to give a talk on “Chemical imaging-based insights into the human gut microbiome- drug interaction network” at the CMFI - Cluster of Excellence (CoE) at the Univ. of Tübingen.
@microbesplanet.bsky.social & @cemess.bsky.social
#MicroSky 🧪
