Read the thread by first author Bohdana Hurieva, who explains our findings on the catalyitc activities of animal TIRs in more details:
bsky.app/profile/bhur...
Sorek Lab
🎉Excited to share our new preprint!
TIR domains from diverse animals, including human TLR4, are catalytically active and produce cyclic ADP-ribose (cADPR). This enzymatic activity is widespread in animals and conserved across the tree of life.
www.biorxiv.org/content/10.6...
