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Emmy Noether Research Group Leader Immuno-Materials @ Leibniz INM and @ MaxPlanck Bristol | Combining SynBio and immunology with synthetic cells, biophysics, organoids
Oskar Staufer









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4mo
Was a pleasure to report on our synthetic immunology approach and how we use synthetic cells to improve immunotherapy 🎧
Very happy to have you onboard Marion!
New paper out in NatureComm: We built synthetic immune cells that self-assemble with cancer cells into hybrid tumoroids, enabling bottom-up reconstruction of the tumor immune microenvironment. rdcu.be/eUmRM @leibnizinm.bsky.social
Oskar Staufer
6mo
Excited to share our new @pnas.org paper! We used reconstitution approaches and synthetic cells to uncover what drives bispecific T cell engagers efficiency. This helps future #immunotherapy design and demonstrates the potential of synthetic cells in #immunoengineering: www.pnas.org/doi/10.1073/...
Apr 29, 2025
May 31, 2025
🌱 New beginnings, fresh faces! As our pilot phase wraps up, the school is ready to grow and thrive. We’re thrilled to welcome 18 new fellows to the #MatterToLife Faculty 🎉 Each brings exciting perspectives from across interdisciplinary research. mattertolife.maxplanckschools.org/355008/new-f...
Oskar Staufer
Oskar Staufer
Bispecific T cell engagers (TcEs) link T cell receptors to tumor-associated antigens on cancer cells, forming cytotoxic immunological synapses (IS)...
www.pnas.org
Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency | PNAS
Building tissues from the bottom up! In Advanced Healthcare Materials @wiley.com, @ostaufer.bsky.social and co-authors show synthetic cells forming lymph-node-like tissues that host immune cells -towards building synthetic organs. doi.org/10.1002/adhm... #academicsky 🧪
Congrats to Saarbrücken researchers! Prof. Karin Jacobs, Prof. Franziska Lautenschläger & @ostaufer.bsky.social join the Max Planck School Matter to Life as Fellows, strengthening biophysics & soft matter research in Germany. #academicsky #science
Oskar Staufer
8mo
7mo
9mo
New paper from the Staufer Lab - Immuno Materials, a group that seeks to build immunity from the bottom-up
Jun 2, 2025
Apply now to join my group as a postdoctoral Fellow at @imperialcollege We are supporting applications for: - Imperial College Research Fellowship -Marie Skłodowska-Curie Postdoctoral Fellowships Get in touch: continilab.com #SoftMatter, #CellMimicry #polymerchemistry
Max Planck School Matter to Life
Leibniz INM
May 30, 2025
Leibniz INM
New paper out! Would you like to fluorescently label the plasma membrane in live, fixed or permeabilized cells? I tested different lipid structures and labelling approaches to decide what makes a good membrane labelling probe for such imaging experiments! www.biorxiv.org/content/10.1...
May 13, 2025
European Synthetic Cell Initiative
Video
Claudia Contini
Erdinc Sezgin
Matter to Life welcomes 18 new Fellows, enhancing innovative research and mentorship opportunities for PhD candidates starting this October.
mattertolife.maxplanckschools.org
New Faculty Members from October 2025
We are super excited to announce that Marion has joined our #MSCA-DN to work in the @ostaufer.bsky.social lab. The project will focus on the development of #SyntheticCell models that mimic #Age-RelatedDiseases. More details: www.comeincell.org/dc04-synthet... Welcome Marion! #HorizonEurope
Apr 29, 2025
ComeInCell
www.biorxiv.org
Labeling the plasma membrane for advanced imaging remains a significant challenge. For time-lapse live cell imaging, probe internalization and photobleaching are major limitations affecting most membr...
Plasma membrane labelling efficiency, internalization and partitioning of functionalized fluorescent lipids as a function of lipid structure
Wie künstliche Zellen den #Krebs besiegen könnten. Darüber spricht @ostaufer.bsky.social vom @leibnizinm.bsky.social in der neuen Folge von #TonspurWissen, dem #Podcast von Leibniz-Gemeinschaft und Rheinischer Post. 🎧 👉 pod.fo/e/388f21 #Biologie #Medizin #Immuntherapie #Gesundheit #Wissenschaftsjahr
4mo
Synthetic cells have emerged as a novel biomimetic approach for fundamental research and therapeutic interventions. T cell activating synthetic cells are able to form 3D tissue-like structures by sel....
doi.org
Synthetic Cell‐Based Tissues for Bottom‐Up Assembly of Artificial Lymphatic Organs
Leibniz-Gemeinschaft
May 31, 2025
Excited to share our new @pnas.org paper! We used reconstitution approaches and synthetic cells to uncover what drives bispecific T cell engagers efficiency. This helps future #immunotherapy design and demonstrates the potential of synthetic cells in #immunoengineering: www.pnas.org/doi/10.1073/...
Bispecific T cell engagers (TcEs) link T cell receptors to tumor-associated antigens on cancer cells, forming cytotoxic immunological synapses (IS)...
www.pnas.org
Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency | PNAS
Oskar Staufer