Out today in @cp-molcell.bsky.social!
We show that proximal polyadenylation site (pPAS) within MRE11 sustains its transcription through promoter–PAS chromatin looping.
Congratulations to first author Kaimeng Huang, all co-authors and collaborators.
www.sciencedirect.com/science/arti...
Thank you for highlighting our work!
It's a wrap! Thanks to all the organisers (@haicovanattikum.bsky.social, @titiasixma.bsky.social, @sylvie-noordermeer.bsky.social, @luijsterburglab.bsky.social, @thedownslab.bsky.social, and many others) for assembling this fantastic conference. One of the best meetings I have attended so far!
Excited to share our new review in Molecular Cell on replicative single-stranded DNA gaps and their role in genome instability and cancer therapy.
#DNARepair #ReplicationStress #GenomeStability #CancerResearch #MolecularBiology #PARPinhibitors
www.cell.com/molecular-ce...
Great to see this team effort out, in which we find a new player in genome stability and a neurodevelopmental disease caused by its loss. Fantastic collaboration with @drjhujh.bsky.social and @profstewartlab.bsky.social alongside @sorenhough.bsky.social and friends in @spjacksongroup.bsky.social.
Thrilled to share our latest work - now available in full in Nature Communications - led in my lab by @vcherdy.bsky.social, with key collaborative contributions from @nitikataneja.bsky.social .
rdcu.be/eVrxX
🎉 Congratulations to Steven Fesik and Neil Osheroff, who have been honored with 2026 awards from The Protein Society.
Learn more about their prestigious awards 👉 www.proteinsociety.org/protein-soci...
Alternative polyadenylation (APA) generates transcript isoforms with variable 3′ untranslated regions (UTR) lengths, yet its role in DNA damage respon…
Replicative single-stranded DNA gaps arise when DNA synthesis proceeds past lesions
or difficult-to-replicate regions. This review delineates the pathways that generate,
stabilize, and process these i...
Nature Communications - Replication fork plasticity upon genotoxic stress is modulated by nuclear architectural components by elusive mechanisms. Here the authors implicate Lamin A/C – best...
Happy holiday, everyone! 2026 Social DNAing Schedule is now online. Here is a sneak peek. Check it out and sign up at www.cancer.columbia.edu/research/pro...
An in-press version of our latest paper in @natcomms.nature.com on phospho-activated protein-protein interactions with ssDNA-binding protein RPA during BIR. If your favorite pathway involves RPA, this may be for you! Thanks to the lab, collaborators & @ukri.org!
www.nature.com/articles/s41...
Chowdhury Lab
Chowdhury Lab
Basil Greber
Vincenzo Costanzo
Chris Carnie
Lopes_Lab
TPS awards recognize excellence across the diverse disciplines that collectively advance our understanding of proteins; their structure, function, design, and application. The Awards honor…
www.proteinsociety.org
1. A new @cp-molcell.bsky.social paper from @chowdhurylab.bsky.social that shows proximal polyadenylation site (pPAS) within MRE11 sustains its transcription through promoter–PAS chromatin looping.
ACS supported this work through Dr. Ke Cong's postdoc fellowship.
doi.org/10.1016/j.mo...
It is almost over, so this seems to be a good time to share a few photos taken during the DNA repair meeting in Egmond aan Zee (mostly in the early mornings before sessions). What a fantastic setting to hold a conference!
Loss of CTLH component MAEA impairs #DNArepair and replication and leads to #DevelopmentalDelay
By S. Hough, S. Jackson & colleagues @cam.ac.uk @cruk-ci.bsky.social
🗞️ doi.org/10.1038/s443...
Happy to share our new review in @annualreviews.bsky.social on abasic sites and their impact on DNA replication written by @angelotaglialatela.bsky.social.
www.annualreviews.org/content/jour...
Apurinic/apyrimidinic (AP) sites, also known as abasic sites, are among the most frequent DNA lesions, arising spontaneously or as intermediates in base excision repair. Their structural impediment to...
