Replicative single-stranded DNA gaps are emerging as central intermediates in the cellular response to replication stress. Replication frequently cont…
Three days, fresh data, & sparkly debates on how replication gaps drive cancer & disease. Grateful for every talk & discussion. Thank you for pushing science forward—next stop: great papers. Science moves fast when we move together!
Excited to share our new review in Molecular Cell on replicative single-stranded DNA gaps and their role in genome instability and cancer therapy.
#DNARepair #ReplicationStress #GenomeStability #CancerResearch #MolecularBiology #PARPinhibitors
www.cell.com/molecular-ce...
Pleased to share our paper. We found surprising widespread glycogen accumulation in A-T due to mitochondrial
impairment that can be improved by targeting the unexpected FNIP2-SERCA2b-axis.
#AtaxiaTelangiectasia #ATM #RareDisease #Metabolism #Mitochondria
www.nature.com/articles/s41...
The Expanding Roles of Homologous Recombination Proteins in Genome Stability
@labvincenzo.bsky.social review how RAD51 shields DNA from nucleolytic processing, promotes fork reversal, suppresses replicative DNA gaps, binds abasic sites to avert cytotoxic conversion
link.springer.com/article/10.1...
