Excited to share our new review in Molecular Cell on replicative single-stranded DNA gaps and their role in genome instability and cancer therapy.
#DNARepair #ReplicationStress #GenomeStability #CancerResearch #MolecularBiology #PARPinhibitorsāāāāāāāāāāāāāāāā
www.cell.com/molecular-ce...
Replicative single-stranded DNA gaps arise when DNA synthesis proceeds past lesions
or difficult-to-replicate regions. This review delineates the pathways that generate,
stabilize, and process these i...
Out today in @cp-molcell.bsky.social!
We show that proximal polyadenylation site (pPAS) within MRE11 sustains its transcription through promoterāPAS chromatin looping.
Congratulations to first author Kaimeng Huang, all co-authors and collaborators.
www.sciencedirect.com/science/arti...
Alternative polyadenylation (APA) generates transcript isoforms with variable 3ā² untranslated regions (UTR) lengths, yet its role in DNA damage responā¦
www.sciencedirect.com
Great to see this team effort out, in which we find a new player in genome stability and a neurodevelopmental disease caused by its loss. Fantastic collaboration with @drjhujh.bsky.social and @profstewartlab.bsky.social alongside @sorenhough.bsky.social and friends in @spjacksongroup.bsky.social.
š Congratulations to Steven Fesik and Neil Osheroff, who have been honored with 2026 awards from The Protein Society.
Learn more about their prestigious awards š www.proteinsociety.org/protein-soci...
An in-press version of our latest paper in @natcomms.nature.com on phospho-activated protein-protein interactions with ssDNA-binding protein RPA during BIR. If your favorite pathway involves RPA, this may be for you! Thanks to the lab, collaborators & @ukri.org!
www.nature.com/articles/s41...
Thrilled to share our latest work - now available in full in Nature Communications - led in my lab by @vcherdy.bsky.social, with key collaborative contributions from @nitikataneja.bsky.social .
rdcu.be/eVrxX
It's a wrap! Thanks to all the organisers (@haicovanattikum.bsky.social, @titiasixma.bsky.social, @sylvie-noordermeer.bsky.social, @luijsterburglab.bsky.social, @thedownslab.bsky.social, and many others) for assembling this fantastic conference. One of the best meetings I have attended so far!
Chowdhury Lab
Chowdhury Lab
TPS awards recognize excellence across the diverse disciplines that collectively advance our understanding of proteins; their structure, function, design, and application. The Awards honorā¦
Nature Communications - Replication fork plasticity upon genotoxic stress is modulated by nuclear architectural components by elusive mechanisms. Here the authors implicate Lamin A/C ā best...
Happy holiday, everyone! 2026 Social DNAing Schedule is now online. Here is a sneak peek. Check it out and sign up at www.cancer.columbia.edu/research/pro...
Basil Greber
1. A new @cp-molcell.bsky.social paper from @chowdhurylab.bsky.social that shows proximal polyadenylation site (pPAS) within MRE11 sustains its transcription through promoterāPAS chromatin looping.
ACS supported this work through Dr. Ke Cong's postdoc fellowship.
doi.org/10.1016/j.mo...
Happy to share our new review in @annualreviews.bsky.social on abasic sites and their impact on DNA replication written by @angelotaglialatela.bsky.social.
www.annualreviews.org/content/jour...
Apurinic/apyrimidinic (AP) sites, also known as abasic sites, are among the most frequent DNA lesions, arising spontaneously or as intermediates in base excision repair. Their structural impediment to...
Loss of CTLH component MAEA impairs #DNArepair and replication and leads to #DevelopmentalDelay
By S. Hough, S. Jackson & colleagues @cam.ac.uk @cruk-ci.bsky.social
šļø doi.org/10.1038/s443...
Alberto Ciccia
EMBO Molecular Medicine
It is almost over, so this seems to be a good time to share a few photos taken during the DNA repair meeting in Egmond aan Zee (mostly in the early mornings before sessions). What a fantastic setting to hold a conference!
