#scientist #mom interested in #DNA repair #mouse genetics #hematopoiesis #immunodeficiency #lymphoma, and #leukemia. opinions are my own.
Zha Lab
Thank Dr. Kunkle, for a really thorough talk on DNA replication polymerases. This week Dr. Olsen will help us understand RAD51. Sign up at www.cancer.columbia.edu/research/pro...
Thank you, Dr. Zhang, for a great talk. Dr. Yi from UCLA will take us to examine the hidden rearrangements - SCE in cancer genomes and, surprisingly, in normal cells as well. Sign up www.cancer.columbia.edu/research/pro...
Unfortunately, due to unforeseen reasons, Social DNAing will be canceled today!
Our new review on NHEJ just came out on G&D genesdev.cshlp.org/cgi/content/... Highlight the 5 phases, and importantly, the 5 protein bridges that bring the 2 DNA ends together for NHEJ. Thank Dr. Geunil Yi, for generating the illustration for all structural models.
This week Dr. Doksani will join Social DNAing to discuss telomere biology! Please note the US is now in summer saving time. Check you local time! www.cancer.columbia.edu/research/pro...
Are you ready for the Summer? Social DNAing is! Check out the 2026 Summer line-up! Please note one schedule change on June 4th, 2026. Please RT! Sign up at cancer.columbia.edu/research/pro...
Drs. Zhu and Jiang in the Zha lab developed FISH probes for murine rDNA (on Addgene:240559), uncovered high somatic and germline heterogeneities in inbred mice, and unique roles of ATM/LIG4/BRCA1 at rDNA, and proposed a model for single-ended DSB at rDNA loci. academic.oup.com/nar/article/...
Why do mammalian cells need PAR, PARP1/2, but yeast does NOT? While studying the impact of PARG inhibition, Isaac in the lab found that extra-PAR sequesters nuclear PAR-binding proteins (XRCC1 and its partners, etc.) into nuclear condensates. biorxiv.org/content/10.6...
Thank Ylli for a wonderful view on telomere. This week, we have another telomere expert visit - Dr. Lottersberger will discuss the role of DNA-PKcs at telomere. Sign up at www.cancer.columbia.edu/research/pro...
Dr. Thomas Kunkel will visit Social DNAing this week. Sign up and tune in! www.cancer.columbia.edu/research/pro...
