Pleased to see our work looking at the impact of cytokine derived therapies / steroids on hematologic progression in #VEXAS led by Benjamin Turturice & Peter Grayson now published in @ard.eular.org www.sciencedirect.com/science/arti...
Excited to share our NHLBI work led by Alice Wu in collaboration with @kingscollegelondon.bsky.social published in @natcomms.nature.com using scRNAseq and CyTOF to explore pathophysiology of immune #aplasticanemia pre and post IST. www.nature.com/articles/s41...
Congrats to FRENVEX for their study on azacitadine in #VEXAS led by Thibault Comont in @bloodjournal.bsky.social Confirmed inflammatory & hematologic responses in >50%. Molecular responses in >2/3rds! Toxicity common especially in first 3 cycles. ashpublications.org/blood/articl...
The NIH goslings making an appearance this spring 🌸🪿
I’m delighted to share our latest work on severe aplastic anaemia, published in Nature Communications. Using advanced single-cell approaches to dissect immune-mediated marrow failure before and after immunotherapy.
A great collaboration with NIH. www.nature.com/articles/s41...
In a new editorial, Dr. Mary Frances McMullin explores the scientific foundations and clinical implications of a study on variant EPO and erythrocytosis. Read the editorial: nej.md/3YmAnNU
@qubelfastofficial.bsky.social #MedSky #Hematology
Emma M. Groarke
Emma M. Groarke
Emma M. Groarke
Emma M. Groarke
The transcriptional phenotype of immune cells associated with severe aplastic anaemia (SAA) may change post immunotherapy. Here the authors analyse single cell transcriptomics of hematopoietic and imm...
Excited to see our NHLBI work on infections and immunodeficiency in patients with #telomere biology disorders now published @bloodjournal.bsky.social >1/3 had significant infection history & nearly 1/2 t-lymphopenia. Fernando Catto & Fernanda Gutierrez-Rodrigues. ashpublications.org/blood/articl...
Excited to share our NHLBI group’s latest work, led by post-doc Hiroki Mizumaki, looking at the role of the adaptive and innate immune system in #VEXAS in @natcomms.nature.com www.nature.com/articles/s41... Bhavisha Patel Fernanda Gutierrez-Rodrigues Neal S Young
Excited to see our review on #VEXAS now out in @thelancet.com A collaborative effort from our amazing NIAMS and NHLBI VEXAS team Bhavisha Patel, Peter Grayson, Alice Fike, Kaitlin Quinn, Ben Turturice www.sciencedirect.com/science/arti...
NEJM.org
New multi center phase 2 study in @bloodadvances.bsky.social looking again at the role of eltrombopag in pediatric #SAA - overall underwhelming in the treatment naive setting. Possible role in relapsed/refractory though very low numbers ashpublications.org/bloodadvance...
