In a new editorial, Dr. Mary Frances McMullin explores the scientific foundations and clinical implications of a study on variant EPO and erythrocytosis. Read the editorial: nej.md/3YmAnNU
@qubelfastofficial.bsky.social #MedSky #Hematology
I’m delighted to share our latest work on severe aplastic anaemia, published in Nature Communications. Using advanced single-cell approaches to dissect immune-mediated marrow failure before and after immunotherapy.
A great collaboration with NIH. www.nature.com/articles/s41...
Congrats to FRENVEX for their study on azacitadine in #VEXAS led by Thibault Comont in @bloodjournal.bsky.social Confirmed inflammatory & hematologic responses in >50%. Molecular responses in >2/3rds! Toxicity common especially in first 3 cycles. ashpublications.org/blood/articl...
NEJM.org
Pleased to see our work looking at the impact of cytokine derived therapies / steroids on hematologic progression in #VEXAS led by Benjamin Turturice & Peter Grayson now published in @ard.eular.org www.sciencedirect.com/science/arti...
Excited to see our review on #VEXAS now out in @thelancet.com A collaborative effort from our amazing NIAMS and NHLBI VEXAS team Bhavisha Patel, Peter Grayson, Alice Fike, Kaitlin Quinn, Ben Turturice www.sciencedirect.com/science/arti...
Excited to see our NHLBI work on infections and immunodeficiency in patients with #telomere biology disorders now published @bloodjournal.bsky.social >1/3 had significant infection history & nearly 1/2 t-lymphopenia. Fernando Catto & Fernanda Gutierrez-Rodrigues. ashpublications.org/blood/articl...
The NIH goslings making an appearance this spring 🌸🪿
Systems Cancer Immunology Group at KCL
New multi center phase 2 study in @bloodadvances.bsky.social looking again at the role of eltrombopag in pediatric #SAA - overall underwhelming in the treatment naive setting. Possible role in relapsed/refractory though very low numbers ashpublications.org/bloodadvance...
Excited to share our NHLBI work led by Alice Wu in collaboration with @kingscollegelondon.bsky.social published in @natcomms.nature.com using scRNAseq and CyTOF to explore pathophysiology of immune #aplasticanemia pre and post IST. www.nature.com/articles/s41...
Excited to share our NHLBI group’s latest work, led by post-doc Hiroki Mizumaki, looking at the role of the adaptive and innate immune system in #VEXAS in @natcomms.nature.com www.nature.com/articles/s41... Bhavisha Patel Fernanda Gutierrez-Rodrigues Neal S Young
www.nature.com
The transcriptional phenotype of immune cells associated with severe aplastic anaemia (SAA) may change post immunotherapy. Here the authors analyse single cell transcriptomics of hematopoietic and imm...
