Johns Hopkins studied 11 hamsters and found SARS-CoV-2 caused lasting cardiac dysautonomia, shifting from early vagal surge to exhaustion, then post-acute reactivation.
Early immune or mitochondrial stress blockade prevented it.
www.sciencedirect.com/science/arti...
China Medical University Children’s Hospital studied 209 children with PASC.
Oscillometry found airway abnormalities in 74.6%, mostly small airway disease, linking chest pain, cough, fatigue and breathlessness to measurable lung changes.
www.sciencedirect.com/science/arti...
CSIR-IGIB studied 57 people and found SARS-CoV-2 infection shifted microbes inside immune cells, enriching opportunistic bacteria in T cells and platelets.
In long recovery, profiles moved closer to healthy balance.
www.cell.com/iscience/ful...
Researchers reviewed Long COVID and ME/CFS studies and found persistent fibrinoid microclots may impair tiny blood vessels.
TEG often showed stronger clots and poor clot breakdown, a possible hypercoagulable state needing trial validation.
journals.lww.com/bloodcoagula...
Drug failure can still teach biology.
BIIB078 worsened a neurodegeneration marker in ALS, anti-TIGIT promise faded in phase III, and Glybera worked but vanished on cost.
www.nature.com/articles/d41...
Gladstone Institutes found SARS-CoV-2 ORF8 can make macrophages easier to infect by raising ACE2 through IL-17RA, then trigger fiery cell death that helps lung cells catch virus too.
A proviral immune loop, shown in cells and mice.
www.biorxiv.org/content/10.6...
Mainz University Medical Centre, 40 patients. Immunoadsorption stripped GPCR autoantibodies from blood, but Long COVID symptoms did not improve versus sham, and adverse events were more common.
www.thelancet.com/journals/lan...
University of New Mexico researchers found SARS-CoV-2 ORF3a hijacks VPS39, misroutes NPC2 and breaks mitochondria-lysosome contacts, trapping cholesterol inside lysosomes.
A direct path from viral protein to cell dysfunction.
www.cell.com/cell-reports...
Latvian Biomedical Research and Study Centre, 81 hospitalized COVID patients.
At 3 months, long COVID blood still showed platelet, complement and vascular injury signals, a clotting linked imprint after severe infection.
www.cell.com/iscience/ful...
Jon Douglas
1413 people with long COVID used ENO Breathe for 6 weeks.
Breathlessness, anxiety, respiratory symptoms, and quality of life improved, supporting digital care while access and privacy barriers remain.
www.thelancet.com/journals/lan...
Post-acute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID syndrome (LCS), is characterized by persistent symptoms following SARS-Co…
In April 2026, the National Institute for Health Care and Research (NIHR) announced
that it would award £2·31 million to projects aimed at preventing chronic health conditions
as part of its Invention...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily targets the respiratory epithelium, yet severe disease features diffuse lung injury and hyperinflammatory syndromes driven by dys...
Goodson et al. show that SARS-CoV-2 ORF3a hijacks VPS39 to disrupt lysosomal cholesterol
egress through coordinated defects in retromer-dependent NPC2 trafficking and mitochondrion-lysosome-contact-de...
