Gladstone Institutes found SARS-CoV-2 ORF8 can make macrophages easier to infect by raising ACE2 through IL-17RA, then trigger fiery cell death that helps lung cells catch virus too.
A proviral immune loop, shown in cells and mice.
www.biorxiv.org/content/10.6...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily targets the respiratory epithelium, yet severe disease features diffuse lung injury and hyperinflammatory syndromes driven by dys...
