University of New Mexico researchers found SARS-CoV-2 ORF3a hijacks VPS39, misroutes NPC2 and breaks mitochondria-lysosome contacts, trapping cholesterol inside lysosomes.
A direct path from viral protein to cell dysfunction.
www.cell.com/cell-reports...
Goodson et al. show that SARS-CoV-2 ORF3a hijacks VPS39 to disrupt lysosomal cholesterol
egress through coordinated defects in retromer-dependent NPC2 trafficking and mitochondrion-lysosome-contact-de...
