The basic sciences are HIRING at UCSF: open recruitment in the Department of Biochemistry & Biophysics. Please share and please apply! aprecruit.ucsf.edu/JPF05702
A new model of #TumorNecrosis👹
Tumor CXCL1➡️myeloid skewing➡️
Ly6C-low Neutrophil forms intravascular #NeutrophilExtracellularTrap➡️
Intratumoral vascular occlusion➡️
Pleomorphic Necrosis-to-Metastasis
a role of TGFβ
@adrover.bsky.social @megeblad.bsky.social Nature 2025
www.nature.com/articles/s41...
Do not miss this great issue on #extracellular #mitochondria in ❤ #cardiovascular patho-physiology‼️ Great opportunity to catch up with literature and very interesting insights from leaders in the field. 👀
www.ahajournals.org/doi/10.1161/...
Excited to announce our new study (w/ @maxkrummel.bsky.social) published today @nature.com: Macrophages “hold our living identities” by taking tiny bites from living cells and presenting this information to CD8 T cells.
www.nature.com/articles/s41...
#immunology #cellbiology @immunox.bsky.social
Excited to share our latest review in #CircRes! We discuss current knowledge of #extracellular #mitochondria forms, mechanisms of release, and #pathophysiological relevance. Great work by Laura Pena and Magda Makuch in leading this effort!
www.ahajournals.org/doi/10.1161/...
#Mitochondria
Blocking interleukin-6 to prevent the inflammation underpinning cardiovascular disease, genetically informed, without increased risk of infection
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Inflammatory mischief managed: How retinoic acid calms heart attacks at the (marrow) source | Science Immunology www.science.org/doi/10.1126/...
University of California, San Francisco is hiring. Apply now!
Macrophages can sample antigens from living cells through a trogocytosis-like mechanism that routes ingested material away from degradation, a finding that delineates a previously unknown pathway...
www.nature.com
Targeting vitamin A metabolism limits emergency hematopoiesis and promotes resolution of inflammation in myocardial infarction.
Here we study the origin of the cardiac cell lineages in the mouse embryo. Separate but coordinated lineages independently specified at gastrulation generate the myocardium and endocardium. Credits: Miquel Sendra & coll: Jorge Dominguez, K. McDole and L. Guinard
authors.elsevier.com/sd/article/S...
NicolasAvilaLab
NicolasAvilaLab
NicolasAvilaLab
@KingOfPathogens
I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13)
www.nature.com/articles/s41...
