Hi Genetics/Comp-Bio community 👋
Interested in mentoring a comp-bio research student in East Africa over the summer? Do you have any experience in bioinformatics, biostats, genome/RNA-seq analyses, ML, or metagenomics? We'd love to have you as a mentor in our new program! 🧵 (1/n)
Thrilled to announce that the Department of Microbiology at the University of Washington, School of Medicine is hiring at the Assistant Professor level (tenure-track)!
The Pacific Northwest is an awesome place to live and do science 🧪🦠. Join us!
apply.interfolio.com/185622
Applications due 8/1.
Kuhn, @maxkrummel.bsky.social et al. demonstrate how local gene editing of cancer-associated fibroblasts alters their cell state and, subsequently, the cellular tumor microenvironment. rupress.org/jem/article/...
📘 Part of JEM #Cancer Collection: rupress.org/jem/collecti...
#EACR2026
We're kicking off our 2026 Interview Series with the 2026 Donald Metcalf Award Winner Ellen Rothenberg, PhD. She dives into her current work, reflects on her most notable discoveries, and offers helpful guidance to early career scientists. Watch now on iseh.org/Publications...
Journal of Experimental Medicine
Patrick S. Mitchell
Tami Gjorgjieva
Amy C Fan (she/her)
Video
We are tremendously inspired by our director Mark Anderson's election to the National Academy of Sciences @nasonline.org
www.nasonline.org/news/2026-na...
ISEH - International Society for Experimental Hematology
Congrats to Tristan & @maxkrummel.bsky.social for this herculean effort to immunoprofile 15 murine tumor models to identify conserved immune networks. An important resource for mapping what we can understand about human cancers from mouse systems.
www.nature.com/articles/s41...
#immunology #cancer
Differential assembly of mouse and human tumor microenvironments @natimmunol.nature.com @maxkrummel.bsky.social
www.nature.com/articles/s41...
UCSF Diabetes Center
In this Resource paper, Krummel and colleagues provide analysis of 15 commonly used syngeneic mouse tumor models and compare these to the diversity of human tumor microenvironments.
Check out this Associate or Senior Editor opportunity @science.org
recruiting.ultipro.com/AME1123ASEM/...
Nature Reviews Immunology, Published online: 11 May 2026; doi:10.1038/s41577-026-01311-4Macrophages continuously ‘nibble’ healthy neighbouring cells, capturing minute amounts of cytosolic material that are preserved in specialized vesicles and preferentially routed for cross-presentation to CD8+ T cells.
Interesting paper on mitochondrial control of cross-presentation in cDC1s: loss of Complex I impairs cross-presentation of cell-associated antigen and alters NAD+/NADH balance. Restoring NAD+/NADH rescues the phenotype, while correcting lipid peroxidation does not.
Amy C Fan (she/her)
Nature Reviews Immunology
Di Jiang
Studies of mouse dendritic cells show that mitochondrial complex I dysfunction can impair antigen cross-presentation, but can be restored by rebalancing redox homeostasis.
Learn more in #ScienceImmunology: https://scim.ag/4usTmo2
Mitochondrial complex I dysfunction in dendritic cells disrupts NAD+/NADH redox balance and impairs antigen cross-presentation.
