Interesting paper on mitochondrial control of cross-presentation in cDC1s: loss of Complex I impairs cross-presentation of cell-associated antigen and alters NAD+/NADH balance. Restoring NAD+/NADH rescues the phenotype, while correcting lipid peroxidation does not.
Amy C Fan (she/her)
Studies of mouse dendritic cells show that mitochondrial complex I dysfunction can impair antigen cross-presentation, but can be restored by rebalancing redox homeostasis.
Learn more in #ScienceImmunology: https://scim.ag/4usTmo2
Mitochondrial complex I dysfunction in dendritic cells disrupts NAD+/NADH redox balance and impairs antigen cross-presentation.
