How do peroxisomal import receptors return to the cytosol while maintaining the membrane's permeability barrier?
We solved cryoEM structures that demonstrate:
1) how receptors find and engage the recycling complex
2) engage with a transiently gated pore
t.co/KhqWKJh758
FACT OF THE DAY. 26 March 1953. In a huge medical breakthrough, US medical researcher Dr Jonas Salk announced that he had created the first polio vaccine. Polio cases fell from 58,000 per year in 1952 to 6,000 by 1958. Salk’s vaccine was replaced by a new one developed by Albert Sabin in 1962.
Extended this (map_salami) a bit - added a movie option which will generate a labeled movie (1080p or 4k) transitioning between all scenes, with a short rocking motion at each scene for depth perception:
Structure of SARS-CoV-2 spike in complex with its co-receptor the neuronal cell adhesion protein contactin1
www.biorxiv.org/content/10.6...
Check out our new preprint. Cool structure by Sabrina Krepel with Bert Janssen.
Thanks to @danielhurdiss.bsky.social @utrechtvirology.bsky.social #covid #pais
Excited to share my postdoc work on the cryo‑EM structure of the budding yeast telomerase holoenzyme! 🧫🧬
It’s been a real privilege to be part of the awesome Kelly Lab @kellythd-nguyen.bsky.social. Grateful as well to the incredible facilities @mrclmb.ac.uk.
Resurfacing this post in the light of #RELION-5.1. Would be interesting to hear people's experiences now that Relion added "real subvolume" extraction.
“There are more things in Heaven and Earth, Horatio, than are dreamt of in your philosophy.”
Video
Video
We present ICECREAM, a self-supervised approach that achieves substantially better denoising and more reliable missing-wedge recovery in cryo-ET, while reducing training and inference time relative to comparable baselines.
Telomerase is a reverse transcriptase that synthesizes telomeric repeats at chromosome ends, safeguarding genome integrity. We present the cryo–electron microscopy structure of the budding yeast telom...
It was a very nice presentation, thanks for coming!
Thanks, but you speakers did such an excellent job with timekeeping I think you could get a job at Deutsche Bahn to revamp their punctuality. Would be a loss for science though.
Oli Clarke
Nate
Prof Frank McDonough
Lars-Anders Carlson
Lars-Anders Carlson
Hongmiao Hu
Structural Biology
Joost Snijder
RELION 5 3D refinement on tomo data often seems to struggle to align objects that old school STA packages handled no problem... does this match everyones experience or is this a me problem?
