ICYMI: New Online! Caveolae mechanics in cellular functions and disease
OK, here we go. This is the good stuff.
An awesome and technically innovatie new paper by good friends of mine including @profsharona.bsky.social, Bill Zagotta, and my next-door science neighbors Professor Suzanne Hoppins and grad student Sophie Hurwitz.
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A new paper in #ScienceSignaling visualizes the delicate ebb and flow of receptors within neurons via the unusual process of transcytosis—helping answer how these cells maintain their function and connectivity in vivo despite their spindly, elongated nature. https://scim.ag/4dlUGl8
🔬🚀 It's out! Run 100s of imaging experiments before touching a microscope. #VLab4Mic reproduces them in silico from PDB/AlphaFold to help you image right first time. From rockstars Damián Martínez & Bruno Saraiva, inaugural preprint of @mariodelr.bsky.social new lab
www.biorxiv.org/content/10.6...
Nature Reviews Molecular Cell Biology, Published online: 02 June 2026; doi:10.1038/s41580-026-00964-2Caveolae are membrane invaginations that facilitate cell signalling and act as membrane reservoirs. This Review discusses recent insights into caveolae assembly and disassembly, their roles in mechanotransduction and how impaired caveolae mechanics contribute to human disease.
It was an honor to hear Prof. Sarah Veatch, PhD, deliver yesterday’s Inoué Lecture, discussing how spatiotemporal pair-correlation analysis can recover nanoscale membrane organization in live-cell single-molecule localization #microscopy despite diffusion and molecular motion.
#MBL 🌊 #AQLM 🧫
Sympathetic innervation requires transport of TrkA from the soma surface to the axon.
Hurwitz et al. leverage a novel FRET-based approach to quantify conformational dynamics of Mfn1, a member of the dynamin superfamily that mediates mitochon
And now it's out! Happy that PNAS selected for the cover this SEM image snapped by @samjlord.bsky.social, one of the most evocative visualizations of Euplotes that I have ever encountered.
www.pnas.org/doi/10.1073/...
Stay tuned for what is shaping up to be some fascinating follow-up in the lab...
Better vitrification = better cryo-ET.
We've opened an RFA for two-year grants to advance vitrification techniques for biological samples—welcoming applications from researchers in heat transfer, cryogenics, and materials science.
Apply here: bit.ly/4uip6eJ
Huge thank you to the labs of @christlet.bsky.social, Dylan Owen and @wmarkbates.bsky.social, and to Tayla Shakespeare, who helped us make it happen. #VLab4Mic also heavily uses data from @rcsbpdb.bsky.social, @jonasries.bsky.social and @taraska.bsky.social
Analytical and Quantitative Light Microscopy Course
Video
Justin Taraska
Ricardo Henriques
Biohub
Ben Larson
Congratulations to Damián Martinez, Bruno Saraiva, @taylashakespeare.bsky.social, @wmarkbates.bsky.social, Dylan Owen, @christlet.bsky.social and @henriqueslab.bsky.social
We hope VLab4Mic helps researchers design better experiments and ask better biological questions
💻 vlab4mic.henriqueslab.org
A Virtual Laboratory for Microscopy — simulate fluorescence microscopy experiments before stepping into the microscope room.
What could be more exciting than watching Euplotes scurry around under the microscope? How about adding some raptorial predation by supergiant cannibal cells?
www.biorxiv.org/content/10.1...
Video by Vittorio Boscaro.
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