Final version of our paper on zebrafish pericytes and BBB function is now out in Elife!
Congrats to Oz the first author and all contributors.
elifesciences.org/articles/104...
Now online! Persistent and transient senescent cells contribute to brain-barrier development
Pericytes regulate cerebrovascular development, while vascular smooth muscle cells prevent hemorrhage and blood–brain barrier breakdown at vascular hotspots in juvenile and adult zebrafish.
Senescent cell states arise across brain-barrier cell types during development but diverge in duration and function. Endothelial cells and macrophages enter a transient, inflammatory state, whereas choroid plexus epithelial cells maintain a persistent, non-inflammatory state supporting long-term barrier function. These cells are required for brain-barrier formation and function.
