Now online! Persistent and transient senescent cells contribute to brain-barrier development
Senescent cell states arise across brain-barrier cell types during development but diverge in duration and function. Endothelial cells and macrophages enter a transient, inflammatory state, whereas choroid plexus epithelial cells maintain a persistent, non-inflammatory state supporting long-term barrier function. These cells are required for brain-barrier formation and function.
Final version of our paper on zebrafish pericytes and BBB function is now out in Elife!
Congrats to Oz the first author and all contributors.
elifesciences.org/articles/104...
Pericytes regulate cerebrovascular development, while vascular smooth muscle cells prevent hemorrhage and blood–brain barrier breakdown at vascular hotspots in juvenile and adult zebrafish.
