Developmental and Stem Cell Biology lab at the University of Goettingen
Ufuk GĂĽnesdogan
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📢Magda Koziol @epigenome.bsky.social will be speaking at the DPZ @primatenzentrum.bsky.social in Göttingen this Wednesday.
🗓️11 March ⏰13:00
Join us for an exciting seminar! 👇👇
Exciting breakthrough technology from the lab, now live in
@cellcellpress.bsky.social
! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!
Great to see this work out from our neighbours @mrc-lms.bsky.social driven by Noura Maziak @vaquerizasjm.bsky.social!
With Pico-C they reveal a modular regulatory logic driving genome establishment - congrats to all authors!
Ufuk GĂĽnesdogan
Very excited to share our newest findings! A very long team effort pursued by multiple team members -to frantically reproduce everything over and over-, we show mTOR-Polycomb synergy at promoters of developmental master regulator TFs in ESCs prior to their expression. www.biorxiv.org/content/10.6...
🚨The abstract submission deadline is this Friday 17 April 2026.
Takashi Akera Lab
Enhancers are genetic regions that promote the activation of neighbouring genes. @radaiglesiaslab.bsky.social asks how long-range enhancers maintain specificity by constructing synthetic gene landscapes and exploring how they affect gene activity. #gfe2026
Alvaro's @dev-journal.bsky.social Review⤵
Nucleosome aficionados! Our new review "Nucleosome spacing across cell types, diseases, and ages" is out in NAR: academic.oup.com/nar/article/...
A huge effort to pull together what we’ve learned about nucleosome spacing in many systems. Enjoy!
@milena-bikova.bsky.social @chrsclrksn.bsky.social
De novo formation of cis-regulatory contacts in the absence of NIPBL-driven chromatin loop extrusion
www.nature.com/articles/s41...
Friends Davor Solter and Azim Surani receiving the wonderful Paul Ehrlich and Ludwig Darmstaedter Prize for Genomic Imprinting👏 👍 @Frankfurt Germany. With official talks from politicians using words like Education, Knowledge, Democracy 🙏 @maxplanck.de @gurdoninstitute.bsky.social
Dan Landau
Vicki Metzis
www.biorxiv.org
Aydan Bulut-Karslioglu
the Node
Alex Eve
Evgeny Kvon
Denis Duboule
Summary: This Review discusses recent insights into the factors controlling enhancer specificity and how this might help us understand the genetic basis of human disease.
The authors deplete the cohesin activator NIPBL during the mitosis-to-G1-phase transition. They observe that structural loop formation is impaired proportionally to loop length, while gene activation ...
Mark your calendars! The @lscn.bsky.social 9th Annual Symposium is happening on 15 May – and it's shaping up to be an unmissable day of cutting-edge science, collaboration, & community! A great line-up has also been announced.
www.eventbrite.co.uk/e/9th-annual...
Teif lab
Excited to share my PhD work!
The question: How is genome organization established? Here, we developed a low-input Micro-C method, Pico-C, and used it to map chromatin architecture across early stages of fly development.
Here’s a quick Blue-torial 🙂 (1/n)
www.nature.com/articles/s41...
