Citation nonsense.
Our paper on Ryanodine Receptor disease mutations gets cited in a paper about nanocellulose...
advanced.onlinelibrary.wiley.com/doi/full/10....
Journals could use an AI tool to weed through irrelevant citations. Or is this entire paper an AI hallucination?
We have a preprint of a book chapter for you: Structural Analysis of Membrane Proteins in Cell-Derived Microvesicles.
We describe how to image membrane proteins in mid-sized vesicles using cryo-electron tomography
zenodo.org/records/1717...
I just did an interview in the Sueddeutsche Zeitung about how we detect cold temperatures — the journalist, Felix Hütten, did a nice job to make it accessible also for non-scientists.
www.sueddeutsche.de/gesundheit/m...
PIP2-driven cytoplasmic domain motions are coupled to Kir2 channel gating, say Eva-Maria Zangerl-Plessl, Anna Stary-Weinzinger, Colin G. Nichols, and Sun-Joo Lee rupress.org/jgp/article/...
@colinnicholslab.bsky.social
#IonChannels #Phospholipids
Our cryo-EM structure of the intermediate state of the KCNQ1 potassium channel is out. Collaborative effort with the David Fedida and Luca Maragliano labs. Cryo-EM work spearheaded by Efthimios Kyriakis, PhD
www.nature.com/articles/s41...
Our latest work : Statins are used to lower plasma cholesterol but often come with muscle-related side effects. Using cryo-EM, we show how multiple statin molecules cooperate to bind RyR1, a calcium release channel mainly found in skeletal muscle.
nature.com/articles/s41...
For the aficionados: we find that 3 statin molecules bind per subunit of RyR1 (12 for a full tetramer). The statins also interact with one another, highlighting an unusual binding mode.
Work spearheaded by Steven Molinarolo.
Special thanks to people at our in-house EM facility
@hrmem.bsky.social
www.science.org/doi/10.1126/...
A study in collaboration with Frank Bosmans. Reproducible protocol to measure the elusive NaV1.9 currents, and revealing a big role for the preIQ region in gating properties.
Very interesting paper from Susan Hamilton's lab, showing that phosphorylation of RyR1 by SPEG kinase can suppress pathological consequences of disease mutations.
www.science.org/doi/10.1126/...
Thanks to the UBC media team for coverage of our statin : RyR1 work. Atorvastatins bind and trigger opening of a calcium release channel critical for muscle contraction.
news.ubc.ca/2025/11/ubc-...
@ubcmedicine.bsky.social
