How do sperm and egg fuse? Surprisingly, we still don’t fully know…
Our field has uncovered many pieces of the fertilization puzzle, but not how they fit together.
We identify ✨ SPARK ✨ - a conserved sperm complex that couples sperm-egg binding to fusion.
tinyurl.com/34cm4xat
Read on! 🧵👇
New preprint alert! Ever wonder if cells can talk to each other? Tunneling nanotubes (TNTs) are tiny bridges between cells used to pass organelles, nucleic acids, proteins & even viruses but we've never seen inside them clearly. Until now! 👇🧵
biorxiv.org/content/10.64898/2026.05.27.728322v1
Video
Victoria Deneke
Eva Karasmanis
Design principles of human membrane protein topology. New study from Haoxi Wu @ox.ac.uk and Ramanujan S Hegde @mrclmb.ac.uk:
rupress.org/jcb/article/...
#membrane #lipid
Journal of Cell Biology
We present:
Index-agnostic oblique plane light sheet microscopy of centimetre-scale cleared tissues at subcellular resolution
www.biorxiv.org/content/10.6...
TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data.
@sholtodavid.bsky.social @johanduchene.bsky.social
reeserichardson.blog/2026/05/28/h...
🚨 New in @natureportfolio.nature.com! 🚨
Excited to share our discovery of Manikomycin—a novel antibiotic tackling the AMR crisis! 🦠
Using cryo-EM, we found it’s the first-in-class to target the ribosomal E-site, blocking tRNA entry and beating multi-drug resistance.
Read: doi.org/10.1038/s415...
doi.org
We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog
reeserichardson.blog
Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of ...
We're happy to announce our new preprint! 🐸 easymode: general pretrained networks for cellular cryo-ET. Segment ~20 cellular features – ribosomes, microtubules, mitochondria, nuclei & more – with zero model training. 🔗 doi.org/10.64898/202... 🧵👇
James Manton
Disrupting phage liquid crystalline droplets restores antibiotic susceptibility in Pseudomonas aeruginosa biofilms out in @plosbiology.org
by @abultarafder.bsky.social and team. Exciting collaboration with @geiselbiofilm.bsky.social @pearce-maths.bsky.social and others
Haaris Ahsan Safdari
Really happy to share our latest work on the dynactin complex. We were so surprised to find that overexpression of dynactin p50 causes part of the dynactin complex to form clusters that contain our recently discovered dynactin assembly factor VezA/vezatin. www.biorxiv.org/content/10.6...
Allegretti Lab
Sub-cellular chemical mapping using correlated cryogenic electron and mass spectrometry imaging
online @natmethods.nature.com, led by Hannah Ochner, collaboration with @catfranco.bsky.social and @kiranrpatil.bsky.social labs
doi.org/10.1038/s415...
Tanmay Bharat
Tanmay Bharat
#Biofilm matrices containing filamentous phages help #Pseudomonas aeruginosa tolerate antibiotics. @abultarafder.bsky.social @tbharat-lab.bsky.social &co show that #nanobody disruption of #phage Pf4 #LiquidCrystalline droplets restores #antibiotic susceptibility @plosbiology.org 🧪 plos.io/4xkd6Mw
