New from our lab @crick.ac.uk.
Nascent proteins emerge from the human ribosome into a cytosol packed with hundreds of different molecular chaperones.
Which chaperones recognise specific nascent chains, and what dictates their binding preferences?
www.biorxiv.org/content/10.6...
3. A curiosity/note of caution: just because a chaperone is found at the translating ribosome, that doesn't mean it binds the nascent polypeptide. TRiC returns to the ribosome late in p53 synthesis by hitchhiking on a mature p53 monomer that assembles with the nascent chain.