I’m really pleased to share that our paper is out in Developmental Cell! NGN3 oscillates in the developing pancreas and controls the timing of cell differentiation via an incoherent feed-forward motif. For more details check out the comments below and DOI: 10.1016/j.devcel.2025.06.004
Just out! Fantastic work from @papalopululab.bsky.social showing bi-directional effects in HES1 and cell-cycle.
Join us online later today for two great talks!
Congratulations to @anzymiller.bsky.social and the fellow PIs for being selected on a great career development opportunity!
Anzy Miller
Excited to share that my latest preprint! We use dual reporters and computation to explore the bistable HES1-HES5 motif and find that oscillations enable a hybrid state characterised by synchrony of HES1 and HES5 resolving into single HES during the development of mouse embryonic spinal cord.
We're very excited to announce that our colleague @anzymiller.bsky.social is about to begin her @dev-journal.bsky.social Pathway to Independence journey! This will provide mentoring and support to emerging researchers in developmental biology and stem cells . journals.biologists.com/dev/pages/pi...
Great work from Mochulska & Francois developing a generative framework for systematically building Dynamical Landscapes of cell fate decision making using modular dynamical components
Important step to interpretable and predictive models of cellular differentiation
www.biorxiv.org/content/10.1...
Our latest "Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data"
A rigorous mathematical foundation for Waddington's landscape to study cell fate decision making
Applied to ventral neural tube development
www.biorxiv.org/content/10.1...
Building a mechanistic understanding of cell fate decisions remains a fundamental goal of developmental biology, with implications for stem cell therapies, regenerative medicine and understanding dise...
www.biorxiv.org
🚀 Physics of Life Student Summer Bursaries 2026 – NOW OPEN!
Are you an undergrad curious about research at the interface of physics & biology? Or a supervisor with a keen student?
👉 Find out more & apply: www.physicsoflife.org.uk/summerbursar...
Join us for the next @physicsoflifeuk.bsky.social PDRA-led Seminar:
Tues 10 June | 🕑 2–3 PM BST | 💻 Zoom
With talks from Petr Sherin & Darryl Overby (Imperial), chaired by @jcammann.bsky.social
Register now for the Zoom link:
forms.gle/epdhsHSW2JVv...
www.biorxiv.org
James Briscoe
James Briscoe
📢 The next UK Physics of Life Network ECR led seminar, will take place on 10th March at 2 pm GMT (online).
🌍 The seminar is open to everyone – we’d love to see you there!
Sign up for the link here: forms.gle/JWCMxtB8BLmn...
PI programme | Development | The Company of Biologists
Development's Pathway to Independence programme
Development is excited to announce our call for our Pathway to Independence program...
Dynamics, dynamics, dynamics! We asked how ER+ breast cancer cells transition from dormancy to reactivation. Inspired by developmental biology, we show that HES1 protein oscillations change during this shift — and that disrupting these dynamics prevents reactivation. www.pnas.org/doi/10.1073/...
Meet the 2025 @dev-journal.bsky.social Pathway to Independence (PI) fellows
Eight developmental and stem cell biologists transitioning from postdoc to principal investigator
journals.biologists.com/dev/pages/pi...
@physicsoflifeuk
In our latest study by @veronicabiga.bsky.social, we explore how the “Oscillatory Co-expression of HES1 and HES5 Enables a Hybrid State in a Bistable Transcription Factor Regulatory Motif”:
www.biorxiv.org/content/10.1...
Long-term recurrence in breast cancer is driven by reactivation of dormant disseminated
tumor cells (DTCs) and remains a major clinical challenge, ...
PI Fellows 2025 | Development | The Company of Biologists
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Many cell fate decisions in the developing neural tube are directed by cross-repressive transcription factor (TF) motifs that generate bistability, enforcing expression of one dominant TF. However, ev...
