I’m really pleased to share that our paper is out in Developmental Cell! NGN3 oscillates in the developing pancreas and controls the timing of cell differentiation via an incoherent feed-forward motif. For more details check out the comments below and DOI: 10.1016/j.devcel.2025.06.004
Our latest study is now available online!
Join us online later today for two great talks!
Our paper on HES1-HES5 is available online and we are excited that it was selected for a Research Highlight online piece!!
Just out! Fantastic work from @papalopululab.bsky.social showing bi-directional effects in HES1 and cell-cycle.
To learn more about this work and the people behind it, we talked to Veronica Biga and Cerys Manning.
journals.biologists.com/dev/article/...
🚀 Physics of Life Student Summer Bursaries 2026 – NOW OPEN!
Are you an undergrad curious about research at the interface of physics & biology? Or a supervisor with a keen student?
👉 Find out more & apply: www.physicsoflife.org.uk/summerbursar...
An oscillatory dance of fate: HES1–HES5 dynamic co-expression precedes cell fate resolution in spinal cord development
This Research Highlight showcases work by Veronica Biga, Cerys Manning @manning-lab.bsky.social and colleagues from @manchester.ac.uk.
journals.biologists.com/dev/article/...
Anzy Miller
As Editor of @dev-journal.bsky.social I get asked "What are you doing about your impact factor?"
In our new editorial we say: Ask not what Dev can do for the impact factor. Ask what you can do for Dev's IF
The IF is about how we all cite, review & assess each other's work
doi.org/10.1242/dev....
Read the Research Article 'Oscillatory co-expression of HES1 and HES5 enables a hybrid state in a cross-repressive transcription factor regulatory motif' here.
journals.biologists.com/dev/article/...
Summary: This Editorial offers an honest look at impact factor trends in developmental biology, explains how Development serves its community, and makes the case that sustaining developmental biology ...
📢 The next UK Physics of Life Network ECR led seminar, will take place on 10th March at 2 pm GMT (online).
🌍 The seminar is open to everyone – we’d love to see you there!
Sign up for the link here: forms.gle/JWCMxtB8BLmn...
James Briscoe
Dynamics, dynamics, dynamics! We asked how ER+ breast cancer cells transition from dormancy to reactivation. Inspired by developmental biology, we show that HES1 protein oscillations change during this shift — and that disrupting these dynamics prevents reactivation. www.pnas.org/doi/10.1073/...
Long-term recurrence in breast cancer is driven by reactivation of dormant disseminated
tumor cells (DTCs) and remains a major clinical challenge, ...
Read the Research Article 'Oscillatory co-expression of HES1 and HES5 enables a hybrid state in a cross-repressive transcription factor regulatory motif' here.
journals.biologists.com/dev/article/...
Development
An oscillatory dance of fate: HES1–HES5 dynamic co-expression precedes cell fate resolution in spinal cord development
This Research Highlight showcases work by Veronica Biga, Cerys Manning @manning-lab.bsky.social and colleagues from @manchester.ac.uk.
journals.biologists.com/dev/article/...
Development
Video
Highlighted Article: Expression of the cross-repressing proteins HES1 and HES5 is mutually exclusive but when they oscillate, a cell can express both, creating a hybrid state that later resolves into…
Highlighted Article: Expression of the cross-repressing proteins HES1 and HES5 is mutually exclusive but when they oscillate, a cell can express both, creating a hybrid state that later resolves into…
