Just out! Fantastic work from @papalopululab.bsky.social showing bi-directional effects in HES1 and cell-cycle.
Dynamics, dynamics, dynamics! We asked how ER+ breast cancer cells transition from dormancy to reactivation. Inspired by developmental biology, we show that HES1 protein oscillations change during this shift — and that disrupting these dynamics prevents reactivation. www.pnas.org/doi/10.1073/...
www.pnas.org
Long-term recurrence in breast cancer is driven by reactivation of dormant disseminated
tumor cells (DTCs) and remains a major clinical challenge, ...
