Excited to share that my latest preprint! We use dual reporters and computation to explore the bistable HES1-HES5 motif and find that oscillations enable a hybrid state characterised by synchrony of HES1 and HES5 resolving into single HES during the development of mouse embryonic spinal cord.
In our latest study by @veronicabiga.bsky.social, we explore how the “Oscillatory Co-expression of HES1 and HES5 Enables a Hybrid State in a Bistable Transcription Factor Regulatory Motif”:
www.biorxiv.org/content/10.1...
www.biorxiv.org
Many cell fate decisions in the developing neural tube are directed by cross-repressive transcription factor (TF) motifs that generate bistability, enforcing expression of one dominant TF. However, ev...
