Cryo-EM structures of human dopamine transporter (hDAT): apo, substrate-bound, & antidepressant-bound. Bupropion binds central pocket in both DAT & NET, explaining dual NRI/DRI action. Vanoxerine traps DAT in outward-open state (distinct pose). K+ occupies Na+ sites, suggesting regulatory role.
14 June 1921 | A Pole, Stanisław Trałka, was born in Wąbrzeźno.
He was deported to #Auschwitz on his 19th birthday in the first transport of Poles to the camp on 14 June 1940.
No. 660
He perished in the camp on 2 October 1942.
Lactate exerts neuroprotective effects through mechanism associated with enhanced 14-3-3 lactylation, reduced NLRP3/GSDMD pathway activation, attenuated GSDMD-associated mitochondrial injury, decreased cytosolic mtDNA levels & suppression of cGAS–STING signaling
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Here, we review mechanistic links between glucocorticoids signaling and systemic aging and discuss strategies to mitigate the age-accelerating consequences of persistent GC exposure.
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Cumulative ultra-processed food intake from 6mo to 6y – NO association with cognitive performance at 2y or 6y. BUT: higher UPF → smaller subcortical volumes at 6y (accumbens, amygdala, pallidum, putamen, thalamus; FDR p<0.05). Each 10% higher UPF → 1.9% smaller volume.
This article summarizes the effects of PM2.5 on the thyroid gland and its potential toxic mechanisms, outlines future research directions, and provides a scientific basis for developing precise protection strategies and air quality standards.
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Knowledgebase of Circadian-Related Risk Factors for Cancer Pathogenesis and Personalized Medicine
bioinf.org.cn:9876
81 meta-analyses, 254M participants
•VitD deficiency in schizophrenia 65%
•Depression in diabetes 62%
•Anxiety in PCOS 48%
•DEP in diabetic foot ulcer 47%
•MCI in T2D 45%
•DEP in PCOS:37%
•DEP in metabolic syndrome 31%
•Anxiety in T1D 21%
•Obesity in autism 17%
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Nature Metabolism, Published online: 27 May 2026; doi:10.1038/s42255-026-01535-7This study reveals that glycogen metabolism is crucial for the sensory activation of POMC neurons, which is necessary for proper feeding behaviour and metabolic health in mice.
Psychiatric disorders frequently co-occur with endocrine, nutritional, and metabolic disorders, complicating diagnosis, treatment, and prognosis. To d…
Insomnia is the most prevalent sleep complaint, occurring as a primary or comorbid condition, increasing the public healthcare burden. Prior reviews e…
