@schvartzman.bsky.social and I wrote a perspective on how dynamic metabolite-protein interactions can shape cell biology, and the open questions this raises about the broad roles of metabolism. It was fun to dig into Zabala-Letona, Carracedo et al.'s story as an example of this! tinyurl.com/4tcnrydm
Funding uncertainty will inevitably push low-income and marginalized students towards financially stable opportunities. I’m not sure I would’ve pursued a career in research if I was starting now as opposed to ten years ago. We need to double down on our efforts to support diverse young scientists.
Gently wondering if it might be possible to nurture a professional culture that doesn’t require its newest members to crowdsource survival tactics..
Zabala-Letona et al. here: www.nature.com/articles/s41...
University bridge funding policy is wonky and little-discussed but is going to have such a massive impact on the direction of research and size and composition of the scientific workforce. I wrote a little about it - tl;dr if you're an academic you should get curious about your institution's policy!
Sen. Ossoff: Who out there in the American public is sitting at home demanding that we shut down cancer research and Alzheimer's research?
In a recent article in Nature, Zabala-Letona et al.1 propose that polyamines—small, positively charged metabolites—regulate RNA splicing by electrosta…
Polyamines prevent the action of kinases on acidic phosphorylatable motifs in spliceosomal proteins, thus providing a mechanism for metabolite-mediated regulation of alternative splicing in cells.
www.nature.com
Recent multi-pronged efforts to limit the autonomy, financial solvency, and influence of American universities have included federal funding cuts impacting research programs across disciplines.
Grant cancellations of any kind are terrible and disruptive, but I've been thinking a lot about the compounding effects that cancelling trainee grants will have - so many promising young people left discouraged and (rightfully) contemplating careers outside of science.
