Maintaining transcriptome solubility constrains mRNA sequence composition
Exploring the propensity for self-association of the transcriptome via RNA–RNA interactions!
Amazing preprint by Marco Todisco, Christalyn Ausler and Ankur Jain.
www.biorxiv.org/content/10.1...
www.biorxiv.org
Have you ever wondered how chromatin states shape developmental trajectories? In our preprint, we address this question using single-cell nanoCUT&Tag, a method developed by Marek Bartosovic @mardzix.bsky.social, which simultaneously profiles active H3K27ac and repressive H3K27me3 in the same nucleus
Mitochondria tethered to the nucleus secure its energy supply
📣 Preprint alert! We developed a method to analyze concurrent interactions between multiple chromatin regions at single alleles at sub-nucleosome resolution (multi-way Micro-Capture-C, mwMCC) & used this to study structural synergy within super-enhancers. 1/14
www.biorxiv.org/content/10.6...
I am so happy to see our paper on spatial feature based analysis of chromatin states in print in Nature Communications. Here is an early access version of O-SNAP: www.nature.com/articles/s41...
Sub-cellular architectures arise through integrating signaling and structure. @edenchang.bsky.social and @zjmaggiexu.bsky.social show how coupling reaction-diffusion signaling to protein condensation provides a tunable, regulatable landscape for sub-cellular structure www.biorxiv.org/content/10.6...
Let's step inside a neuron together, and ask, "how did all this get here?" 🤔 In this review, I trace the history and transformations of a neuron's molecules, pay homage to major discoveries in brain development ... and make a call to action for neuroscience.
www.annualreviews.org/content/jour...
www.biorxiv.org
Mitochondria interact directly with the nuclear pore complex via VDAC1–RANBP2 binding to sustain nuclear ATP levels.
Neurodevelopment is the transformation of genetic information into diverse neuronal phenotypes. Developmental signals initiate patterns of gene transcription and translation that drive progenitors tow...
www.nature.com
Changes in nuclear architecture during cell state transitions remain poorly understood. Here, the authors use O-SNAP, a framework to analyze SMLM images of chromatin, to reveal chromatin remodelling i...
Iron-rich immune cells within homing pigeons’ livers seem to give the birds their magnetic compass. https://scim.ag/4tYuK5r
Video
Out now in Science! Our study challenges long-standing assumptions about transcription factor specificity in eukaryotes. Novel single-molecule measurements of TF behavior in living cells reveal an independence of locus-specific binding from DNA sequence recognition.🧵
www.science.org/doi/10.1126/...
Marieke Oudelaar
Scott Coyle
Matthew L. Kraushar
Video
New study identifies a surprising mechanism for sensing Earth’s magnetic field
How intrinsically disordered regions (IDRs) shape chromatin binding and nuclear organization of transcription factors (TFs) remains unclear. We used proximity-assisted photoactivation (PAPA), a single...
