Chromatin fatigue: DNA repair alters the chromatin environment and introduces heritable variation in gene expression in a larger region around the lesion! Amazing achievement by @sbantele.bsky.social and Jiri Lukas published in @science.org ๐ Happy we could contribute. See ๐
Learn about the #DNAdamage response in #CellPhysiology and diseases in the eponymous EMBO Workshop in #Sounio, #Greece, 12โ16 October 2026.
Deadline: 17 May 2026
https://meetings.embo.org/event/26-dna-damage
#EMBODNADamageResponse #genesky #LifeSciences #research #meeting #EMBOevents ๐งช
๐ The final version of our paper is out in press
Cohesin cofactor dosage sets the rate of loop extrusion, rendering genome folding tunable yet vulnerable to genetic disruption
authors.elsevier.com/a/1m%7EU03vV...
or www.cell.com/molecular-ce...
Registration open. Top-notch lineup of speakers from Europe, the US and beyond, covering chromatin biology, genome maintenance, cancer plasticity and evolution, and metabolism www.atoutcom.com/cancer-epige...
๐ข Don't miss @groth-anja.bsky.social from the Danish Cancer Institute, who will present her research at the #Embryo2026 ๐งฌ
"How cells copy their epigenome"
Register until Oct 31! ๐
www.molgen.mpg.de/embryo2026
Supported by the Weizmann Institute of Science
Join us for the 3rd EMBO:EMBL Symposium on 'DNA replication and Genome Maintenance - from basic biology to human health' @embl.org
Heidelberg, Oct 20-23 2026. Fantastic speaker lineup ๐คฉ on chromosome replication, stability and organization ๐ abstract by July 28: s.embl.org/ees26-13-li
๐งชMove over CUT&Tag, thereโs a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
๐ Our @natcomms.nature.com paper: www.nature.com/articles/s41...
๐งตLetโs break down what makes DynaTag so powerful (1/7)
Shah, Tortora, et al. show that cells can dial the rate of cohesin loop extrusion
by balancing the relative dosage of NIPBL and PDS5. Their models provide a quantitative
mechanistic basis for the gene...
Yadav, Jadhav, @hanasedlackova.bsky.social et al present a novel cell-permeable biotin-HaloTag ligand. The reported ligand expands the HaloTag toolbox by enabling in vivo labeling & providing capabilities for efficient affinity capture of protein variants from live cells rupress.org/jcb/article/...
Anja Groth
Scaffidi Lab
This is really bad. The ERC is the lifeline of many labs. The letter from the ERC says โthe only way is to reduce applicationsโ No! It's the wrong direction.
Use AI to assist review. Itโs not perfect, but it allows more proposals to be evaluated, and it should support, not replace, human reviewers.
Max Planck Institute for Molecular Genetics
Robert Hรคnsel-Hertsch
Elphege Nora Lab at UCSF
DNA replication globally disrupts the epigenome. But does this create a chromatin-access opportunity for TF binding to facilitate cell identity change? Now ๐ซ๐๐ฉ๐ฅ๐ข-๐๐๐๐-๐ฌ๐๐ช shows ๐ฅ๐ฆ ๐ฏ๐ฐ๐ท๐ฐ chromatin opening & TF binding occurs specifically post-replication, in cellular differentiation & reprogramming!
Knudsen and colleagues use repli-ATAC-seq to compare replicated and unreplicated chromatin
in two models of cell identity change. They find that lineage-specific elements are
accessible earlier in rep...
๐๐ฎ๐ป ๐ฐ๐ฒ๐น๐น๐ ๐ฒ๐๐ฒ๐ฟ ๐๐ฟ๐๐น๐ ๐ฟ๐ฒ๐ฐ๐ผ๐๐ฒ๐ฟ ๐ณ๐ฟ๐ผ๐บ ๐๐ก๐ ๐ฑ๐ฎ๐บ๐ฎ๐ด๐ฒ?Excited to share our new study โRepair of DNA double-strand breaks leaves heritable impairment to genome functionโ, revealing DNA repairโs hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.๐งต๐1/n
Journal of Cell Biology
Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...
New preprint with @gfudenberg.bsky.social
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. ๐งต๐
www.biorxiv.org/content/10.1...
Cohesin loop extrusion is a major driver of chromosome folding, but how its dynamics are controlled to shape the genome remains elusive. Here we disentangle the contributions of the cohesin cofactors ...
I donโt know if you saw the MASSIVE news announced by @erc.europa.eu today: from now on, if you get a B at step 1 you are eligible to apply at N+3(!!!) years. Say you got a B in STG2026 step 1, you thought you could apply in STG2028, but no: only in STG2029! erc.europa.eu/news-events/...
The ERC plans to launch the grant competitions under its 2027 Work Programme between July 2026 and June 2027, with the calls for proposals introducing several changes to the eligibility rules for appl...
