Chromatin fatigue: DNA repair alters the chromatin environment and introduces heritable variation in gene expression in a larger region around the lesion! Amazing achievement by @sbantele.bsky.social and Jiri Lukas published in @science.org ๐ Happy we could contribute. See ๐
๐๐ฎ๐ป ๐ฐ๐ฒ๐น๐น๐ ๐ฒ๐๐ฒ๐ฟ ๐๐ฟ๐๐น๐ ๐ฟ๐ฒ๐ฐ๐ผ๐๐ฒ๐ฟ ๐ณ๐ฟ๐ผ๐บ ๐๐ก๐ ๐ฑ๐ฎ๐บ๐ฎ๐ด๐ฒ?Excited to share our new study โRepair of DNA double-strand breaks leaves heritable impairment to genome functionโ, revealing DNA repairโs hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.๐งต๐1/n
Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...
