📖 The final version of our paper is out in press
Cohesin cofactor dosage sets the rate of loop extrusion, rendering genome folding tunable yet vulnerable to genetic disruption
authors.elsevier.com/a/1m%7EU03vV...
or www.cell.com/molecular-ce...
Shah, Tortora, et al. show that cells can dial the rate of cohesin loop extrusion
by balancing the relative dosage of NIPBL and PDS5. Their models provide a quantitative
mechanistic basis for the gene...
www.cell.com
Elphege Nora Lab at UCSF
New preprint with @gfudenberg.bsky.social
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
Cohesin loop extrusion is a major driver of chromosome folding, but how its dynamics are controlled to shape the genome remains elusive. Here we disentangle the contributions of the cohesin cofactors ...
