New Preprint in collaboration with GoogleDeepMind: AI-guided discovery of atypical protein assemblies
The @kamounlab.bsky.social discovered an 11-protomer complex thanks to the Structural Novelty Index , a new way to use AlphaFold to find protein assemblies that break the pattern.
@khongsamchia.bsky.social
Extremely excited to share the first pre-print from my PhD project in the Carella lab, co-first authored with @khongsamchia.bsky.social 🎉 (Thread below ⬇️)
www.biorxiv.org/content/10.6...
Huge thanks to all co-authors and the #CarellaCapybaras for all the support 😊
Check out our latest pre-print on the evolution of TIR activity/signalling: www.biorxiv.org/content/10.6...
Fun thread. Cool work, and make sure to read all the way to the end!
End of April and I got my diploma🥂 Now the PhD degree is official! I hope I've mentioned everyone in my acknowledgments, but I still can’t thank you enough for all the support along this journey: ) If anyone's looking for some 400-page light reading… here it is ➡️ ueaeprints.uea.ac.uk/id/eprint/10...
Finally made it.... congratulations all.
Preprint Alert 🚨 @philcarella.bsky.social lab stepping into TIR-ritory!! Project started by me but finished by talented PhD student @ebkennedy.bsky.social (Please follow her), with contribution from Zhao He and @jonathandgjones.bsky.social We investigated EDS1-dependency of TIR domain. See thread👇
So proud to see this story finally out!🎉 We added new data since our previous preprint—transgenic barley plants with an engineered immune receptor that fights off two fungal pathogens at once. Short 🧵 and link to the original preprint thread on X👇
www.science.org/doi/10.1126/...
📢 PDRA Position - Plant Immune Receptor Bioengineering at Imperial College London
🌱 Start: Aug 2026 (flexible)
🧪 Wet lab + bioinformatics
📅 Up to 3 years (ERC-funded)
📍 South Kensington, on site
ℹ️ shorturl.at/VIITk
🔗 kourelislab.com
#PlantImmunity #PlantPathology
🙏 Share with interested candidates!
Just published: Breaking the Pattern with AlphaFold: Introducing the Structural Novelty Index
AlphaFold has transformed how we predict protein structures. But sometimes most interesting discoveries come from asking a different question: which proteins break the pattern?
medium.com/p/breaking-t...
Artificial intelligence (AI) systems such as AlphaFold have transformed structural biology by enabling accurate prediction of protein structures. However, their capacity to uncover new classes of…
Plants and animals respond to pathogen attack by mounting innate immune responses that require intracellular nucleotide-binding leucine-rich repeat (NLR) proteins. These immune receptors detect pathog...
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
@khongsamchia.bsky.social
Extremely excited to share the first pre-print from my PhD project in the Carella lab, co-first authored with @khongsamchia.bsky.social 🎉 (Thread below ⬇️)
www.biorxiv.org/content/10.6...
Huge thanks to all co-authors and the #CarellaCapybaras for all the support 😊
Sophien Kamoun
Protein structure prediction changed biology. Protein assembly discovery is next.
We present SNI (Structural Novelty Index), a scalable framework for finding new protein complexes.
We used it to uncover an unexpected resistosome assembly: 11-mer. 🧵👇🏻
biorxiv.org/content/10.6...
@khongsamchia.bsky.social
Extremely excited to share the first pre-print from my PhD project in the Carella lab, co-first authored with @khongsamchia.bsky.social 🎉 (Thread below ⬇️)
www.biorxiv.org/content/10.6...
Huge thanks to all co-authors and the #CarellaCapybaras for all the support 😊
The variable wheat stripe rust effector AvrYr7 evades Yr7 recognition through sequence and expression polymorphisms https://www.biorxiv.org/content/10.64898/2026.05.09.724051v1
