Kuhn, @maxkrummel.bsky.social et al. demonstrate how local gene editing of cancer-associated fibroblasts alters their cell state and, subsequently, the cellular tumor microenvironment rupress.org/jem/article/...
#TME #CAFs #TumorImmunology
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#ScienceRevolution #PeerImprovement #DiscoveryStackPilot #immunosky
If dendritic cells are part of your science,
#DC2026 should be part of your year!
🌍Global DC community in San Diego
✳️New biology & discoveries
Abstracts & registration are OPEN
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⭐️ Come for the science. Stay for the community. @maxkrummel.bsky.social @zunigalab.bsky.social 🔁
Intravital imaging of pulmonary lymphatics in #inflammation and metastatic cancer. A new imaging approach developed by Simon Cleary (@simoncleary.bsky.social), Longhui Qiu, Mark Looney and colleagues: https://buff.ly/41msQjZ
@maxkrummel.bsky.social
Journal of Experimental Medicine
Are so-called 'M2-like' CD206+ macrophages immunosuppressive? On the contrary, we find that they are critical for T cell mediated anti-tumor immunity. Arja Ray drove this study with help from Ken Hu, Kelly Kersten, Alexis Combes and others
www.biorxiv.org/content/10.1...
Journal of Experimental Medicine
In @jem.org, Kuhn, @maxkrummel.bsky.social et al. demonstrate how local gene editing of cancer-associated fibroblasts alters their cell state and, subsequently, the cellular tumor microenvironment rupress.org/jem/article/...
#TME #CAFs #TumorImmunology
www.biorxiv.org
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
How will our increasingly deep understanding of diverse immune archetypes in cancers guide our search for cures?
This perspective describes a future in which we discover drugs based on transitions of tissue/immunobiology through intermediate states, to health. authors.elsevier.com/a/1llig5TA51...
Registration is now open and an all-in roster of immunologists anchor the premiere Dendritic cell meeting. www.dc2026sandiego.com/invited-spea... Sunny (blue state) San Diego. Sessions devoted to honoring 15 year anniversary of Nobel prize (Steinman) and translational advances…what is not to like.?
Many tx studies (Mujal... Azizi…)failed to validate M1/M2 signatures in vivo. Many also suspected that calling cells bearing ‘prototypical M2’ genes ‘‘immunosuppressive’ was simplistic + incorrect. Nonetheless many (us too!) leaned on the simplification. Arja addresses the reality head on…thnx JEM
Rockefeller University Press
Max Krummel
Max Krummel
Max Krummel
Max Krummel
Rather than immune suppression, CD206+ TAMs recruit a tumor-reactive network of CD8 T cells, cDC1s, and NK cells
doi.org/10.1084/jem....
@maxkrummel.bsky.social @jexpmed.bsky.social
