HUGE congratulations to our very own Julia Brunner for her paper describing cell-state dependent engagement of the malate-aspartate shuttle, out today!! Many thanks to all lab members, funders, and colleagues who supported the work, and stay tuned for more from Julia very soon!
📣 First preprint from the TeSlaa lab 📣 We investigated how methyl-rich nutrient, choline, is used in the body and how systemic one-carbon metabolism responds to dietary methyl-donor deficiency.
www.biorxiv.org/content/10.6...
Congrats (again) to Julia and Abby for their collaborative effort asking when and why cells use the TCA cycle. TLDR; it's not just about ATP or making nutrients-- the TCA cycle is also important to remove nutrients!
Now online! Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle
1st McKinley Lab grad student’s 1st preprint!
@claireang.bsky.social studied how the uterus safely excises massive amounts of tissue during menstruation and pregnancy.
Come for her GORGEOUS images, stay for her incredible discoveries.
www.biorxiv.org/content/10.6...
w/ @akelleher1017.bsky.social
Check out our Spotlight in Molecular Cell on @lydiafinley.bsky.social's lab recent work on Aconitase 2 and its protective role against impaired cell fitness and ISR activation due to mitochondrial citrate accumulation authors.elsevier.com/c/1n3Nn3vVUP...
#NatMetabPicks | In @cp-cell.bsky.social led by @lydiafinley.bsky.social ( @mskcancercenter.bsky.social ) 🧪
Citrate clearance is an essential function of the TCA cycle via the activity of aconitase 2.
www.cell.com/cell/fulltex...
www.biorxiv.org
Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increase, aconitase 2 becomes essential to prevent mitochondrial citrate accumulation, which can trigger the integrated stress response and impair cell fitness.
Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the
canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation
and citrate production increa...
🍰Read also the Research Briefing here:
👉https://rdcu.be/e3tiZ
bit.ly/404rclA
Cell - a Cell Press journal
☕Yashinskie, Zhu et al show that #p53 activation triggers increased synthesis and accumulation of phospholipids, with enhanced activation of #autophagy and lysosomal catabolism programmes and increased reliance on lipid headgroup recycling. @lydiafinley.bsky.social
bit.ly/4asbwO3
We are hiring a postdoc! The group has a funded opening to join our amazing team on the NCI's Frederick, MD campus.
This is an opportunity to train in cutting-edge chemical & RNA biology methods with a supportive, tight-knit group.
Link to posting below. Please share!
jobrxiv.org/job/national...
The transcription factor p53 enables phosphoethanolamine scavenging to support increased membrane phospholipid synthesis during senescence. Perturbing lipid synthesis or recycling compromises the fitn...
bit.ly
Eddie Rashan
Yashinskie, Zhu and colleagues show that p53 activation triggers increased synthesis and accumulation of phospholipids, with enhanced activation of autophagy and lysosomal catabolism programmes and in...
A big chunk of my postdoctoral work on cell-state dependent metabolism is now out at @cp-molcell.bsky.social: www.cell.com/molecular-ce... 1/
Nature Cell Biology
Nature Cell Biology
Jordan Meier
Brunner et al. report that malate-aspartate shuttle engagement is cell-state dependent
and can be modulated by the availability of the amino acid aspartate. In differentiated
cells, malate-aspartate s...
www.cell.com
One more thing- here, together with amazing human being, friend & stellar physician scientist Abby Xie, we identify a new function of the TCA cycle, which is citrate clearance, now online at @cellpress.bsky.social: www.cell.com/cell/fulltex...
Excited to share my new preprint from the McKinley lab, where we explored regenerative mechanisms across menstruation and pregnancy! We thought specialized glands would regenerate everything.
We were wrong.
But the real mechanism turned out to be way cooler :) 🧪🧵
www.biorxiv.org/content/10.6...
Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the
canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation
and citrate production increa...
