Very happy to share our new paper. Together with our wonderful collaborators, we found that L-2-HG, a metabolite often viewed as “toxic,” also has an essential physiological function in mice. www.nature.com/articles/s41...
Thank you so much for highlighting our work- Truly spot on and a great title!
l-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and funct...
Check out our Spotlight in Molecular Cell on @lydiafinley.bsky.social's lab recent work on Aconitase 2 and its protective role against impaired cell fitness and ISR activation due to mitochondrial citrate accumulation authors.elsevier.com/c/1n3Nn3vVUP...
Ram Chakrabarty
Julia S. Brunner
#NatMetabPicks | In @cp-cell.bsky.social led by @lydiafinley.bsky.social ( @mskcancercenter.bsky.social ) 🧪
Citrate clearance is an essential function of the TCA cycle via the activity of aconitase 2.
www.cell.com/cell/fulltex...
Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the
canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation
and citrate production increa...
Now online! Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle
Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increase, aconitase 2 becomes essential to prevent mitochondrial citrate accumulation, which can trigger the integrated stress response and impair cell fitness.
Julia’s paper identifying Aspartate as a determinant cell-state specific engagement of the Malate-Aspartate-Shuttle is now out @cp-molcell.bsky.social!
Cell - a Cell Press journal
The main function of the TCA cycle is to feed electrons into the respiratory chain.
..wait, what!? It also clears excess citrate, because otherwise you get severe kidney damage?
Great example that textbooks aren’t always the full story by Abby, @juliabrunner.bsky.social and @lydiafinley.bsky.social
@cp-cell.bsky.social is on 🔥 with #immunemetabolism! Zheng &co show that excessive glycolysis-driven pyrivate cause pyruvylation of STAT1 preventing #interferon signaling 👉 doi.org/10.1016/j.ce... & Finley &co show that ACO2 clears citrate preventing integrated stress response & kidney degeneration👇
We are thrilled to announce the 2026 Zara Weinberg Leading Edge Fellows! 40 remarkable postdocs pursuing transformative research in biological/biomedical sciences.
This is the 7th Leading Edge cohort and we are so excited to welcome them!
www.leadingedgesymposium.org/fellows/
Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the
canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation
and citrate production increa...
Key roles for monocyte-derived cells in CNS metabolism and reveals the pleiotropic beneficial effects of arginine in neuroinflammation @natimmunol.nature.com @schabbauerlab.bsky.social @meduniwien.ac.at
www.nature.com/articles/s41...
Ivan Zanoni
Alex Lercher
Alex Lercher
Waggoner Lab
Leading Edge Fellows Program
A big chunk of my postdoctoral work on cell-state dependent metabolism is now out at @cp-molcell.bsky.social: www.cell.com/molecular-ce... 1/
Brunner et al. report that malate-aspartate shuttle engagement is cell-state dependent
and can be modulated by the availability of the amino acid aspartate. In differentiated
cells, malate-aspartate s...www.cell.com
One more thing- here, together with amazing human being, friend & stellar physician scientist Abby Xie, we identify a new function of the TCA cycle, which is citrate clearance, now online at @cellpress.bsky.social: www.cell.com/cell/fulltex...
Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the
canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation
and citrate production increa...
