@cp-cell.bsky.social is on 🔥 with #immunemetabolism! Zheng &co show that excessive glycolysis-driven pyrivate cause pyruvylation of STAT1 preventing #interferon signaling 👉 doi.org/10.1016/j.ce... & Finley &co show that ACO2 clears citrate preventing integrated stress response & kidney degeneration👇
Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the
canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation
and citrate production increa...
