New NIH Request for Information regarding capping the number of Research Project Grants allowed per investigator.
grants.nih.gov/grants/guide...
Open for comments until August 3rd, 2026
#WeekendRead! #EveryCellIsAnImmuneCell! Brown, Yipp &co show @science.org that platelet cathelicidin initiates antibacterial neutrophil-platelet lung aggregates amplified by LTB4, driving lethal immunothrombi during sepsis! LTB4 blockade maintains antibacterial functions preventing immunopathology!
Check the #ResearchBriefing Kautilya & I wrote about our paper @natimmunol.nature.com doi.org/10.1038/s415... & enjoy some “behind the paper” highlights! 👉👉👉 rdcu.be/flbA1
Thanks for sharing @labwaggoner.bsky.social, nowadays it is not really out there until you do! 🤗
#InterferonPower #InflammasomePower! Thrilled for our 💥#NewPaper💥 @natimmunol.nature.com spearheaded by Kautilya Jena showing that our #fungal adjuvant #Mannadjuvant prolongs & potentiates protection of mRNA vaccines via #IL1b & #IFNs, broadening it to new variants & overcoming antigenic imprinting!
Fantastic work by Aakriti Jain @aakritijain.bsky.social in team
with Claire Goul and the Laboratory for Genome Research reveals the LASER pathway and its core component TFG as critical
for rapid ESCRT-dependent lysosomal membrane repair, pointing to a deep connection with neurodegeneration!
#WeekendRead! #EveryCellIsAnImmuneCell! #RememberMe! Xie, Zeng, Nagree, Jakobsen &co show @nature.com that upon TNF or LPS-driven inflammation, a subset of hematopoietic stem cells retains inflammatory epigenetic memory that can be transferred to immune cell progeny boosting all-cause mortality risk
Eddy, Fardin, and I are happy to share a new review “Defining cell surface and glycosylated RNAs” in an effort to highlight the various sequencing-based tools used to study cell surface RNA biology.
@cp-trendsgenetics.bsky.social #glycoRNA
Happy to share a new review: Functional Inclusion of RNA Biology in the Tethered Extracellular Matrix
We discuss the emerging interface of RNA biology and the ECM. The way biology solved protein-HS interactions is very similar to RNA-protein!
wires.onlinelibrary.wiley.com/doi/10.1002/...
A glycan-based adjuvant expands the breadth and duration of protection of mRNA-based vaccines
www.nature.com/articles/s41... @lozanzi.bsky.social @harvardmed.bsky.social
@natimmunol.nature.com
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Request for Information: Proposal to Cap the Number of Simultaneous Research Project Grants per Principal Investigator ...
Nature Immunology - Jena, Qu et al. show that mannadjuvant, a formulation of fungal mannan and aluminum hydroxide, increases the magnitude, durability and breadth of the response elicited by...
Using xenograft inflammation–recovery models and single-cell multiomics, a haematopoietic stem cell population after inflammatory stress is identified.
A glycan-based adjuvant expands the breadth and duration of protection of mRNA-based vaccines
www.nature.com/articles/s41... @lozanzi.bsky.social @harvardmed.bsky.social
@natimmunol.nature.com
#InterferonPower #InflammasomePower! Thrilled for our 💥#NewPaper💥 @natimmunol.nature.com spearheaded by Kautilya Jena showing that our #fungal adjuvant #Mannadjuvant prolongs & potentiates protection of mRNA vaccines via #IL1b & #IFNs, broadening it to new variants & overcoming antigenic imprinting!
Waggoner Lab
So excited to share our new paper out today in @nature.com - 'LASER couples damage sensing to ESCRT assembly for lysosome repair'. This was an amazing collaborative effort with Claire Goul during our time in @robzonculab.bsky.social : www.nature.com/articles/s41...
Nature Immunology - Jena, Qu et al. show that mannadjuvant, a formulation of fungal mannan and aluminum hydroxide, increases the magnitude, durability and breadth of the response elicited by...
ATG8 conjugation on damaged lysosomes triggers rapid assembly of a protein complex containing TFG, which directs lysosomal membrane repair by recruiting ESCRT proteins to sites of damage.
